The Stuty On Clinical Characteristics And Levels Of IL-6 And AQP5 Of Premature Infants Exposed Tointrauterine And Nrds

Objective: To further clarify the pathogenesis of NRDS by studying the clinical characteristics and IL-6 and AQP-5 levels of NRDS after intrauterine infection,so as to provide evidence for reducing the incidence of NRDS and reducing the morbidity and mortality of newborns.Methods: 2016.1-2017.12 in our Qingdao municipal hospital obstetric delivery,treatment of 131 cases of premature infants parallel placenta examination hospital neonatology,maternal clinical data collection.According to the results of postpartum placenta pathological examination,the patients were divided into two groups: positive group and negative group.The incidence of common diseases in preterm infants and the differences of maternal prenatal and postnatal indexes were compared between the two groups.According to the results of placental pathological diagnosis,47 cases of preterm infants with NRDS were divided into three groups: positive placental pathological diagnosis group and negative placental pathological diagnosis group.According to the severity of the disease,they were divided into three groups: mild,moderate and severe.The levels of interleukin 6(IL-6)and aquaporin 5(aquaporin 5)in plasma were determined by ELISA method.The effects of intrauterine infection on lung injury in children with NRDS were analyzed,and the relationship between plasma IL-6 and AQP5 and severity of lung injury in children with NRDS was studied.Results: 1.There were 38 cases with positive pathological diagnosis(n=38)and 93 cases with negative pathological diagnosis(n=93).The basic data of pregnant women showed that there were significant differences in the incidence of premature rupture of membranes and amniotic fluid abnormality between the two groups(P < 0.05).2.Analysis of the basic data of newborns: the gestational age of newborns in the positive group of pathological diagnosis was smaller than that in the group with negative pathological diagnosis(P < 0.05).The level of procalcitonin in the positive group was significantly higher than that in the negative group on the first day after birth,and the difference was statistically significant(P < 0.05).At the same time,it was found that the incidence of oxygen inhalation time,mechanical ventilation time,hospitalization time and Apgar score ?7 at 5 minutes after birth were slightly higher in the positive pathological diagnosis group than in the negative pathological diagnosis group.The birth weight was lower than that in the negative group,but the difference was not statistically significant(P > 0.05).3.The incidence of brain injury and bronchopulmonary dysplasia in preterm infants in positive pathological diagnosis group was higher than that in negative group with statistical difference(P=0.03,P=0.019).The incidence of neonatal respiratory distress syndrome in the positive group was lower than that in the negative group(P=0.020).There was no significant difference in neonatal hypoglycemia and retinopathy between the two groups.4.There were significant differences in plasma IL-6 and AQP5 between positive group and negative group and normal control group(P<0.05).The levels of plasma IL-6 and AQP5 in the normal control group were lower than those in the NRDS group(P<0.05).The plasma IL-6 and AQP5 levels in the negative pathological diagnosis group were lower than those in the positive group(P<0.05).5.There was significant difference in plasma IL-6 and AQP5 between mild,moderate and severe NRDS groups(P<0.05).The levels of IL-6 and AQP5 in severe group were significantly higher than those in mild group and moderate group(P<0.05).Conclusion:1.Premature premature infants exposed to intrauterine infection had premature rupture of membranes and increased incidence of amniotic fluid abnormalities.2.Prenatal CRP in pregnant women and PCT in preterm infants can be used as laboratory markers for early prediction of intrauterine infection.3.Intrauterine infection increased the incidence of bronchopulmonary dysplasia and neonatal brain injury,but did not increase the incidence of NRDS.4.Plasma IL-6 and AQP5 levels were increased in children with intrauterine infection after exposure.5.IL-6,as an inflammatory cytokine,is involved in the pathogenesis of lung injury.AQP5 can be used as an early indicator to judge the severity of lung injury.