The Relationship Between Metabolic Syndrome And Intracranial Arterial Stenosis In Young Patients With Ischemic Stroke

Objective: to study the metabolic syndrome(MS)and young ischemic stroke patients with intracranial artery stenosis(IAS),for the youth of the merger of intracranial artery stenosis in patients with ischemic stroke provide new therapeutic targets and direction.Methods: collected in August 2015-August 2015 in qing cure of ischemic cerebral apoplexy patients of establishing affiliated hospital,for ages 18 to 45 years old,and the MRA and TCD or CTA or cerebral angiography revealed clear intracranial artery stenosis.The basic information of the study subjects included age,gender,smoking,family history,hypertension,diabetes,obesity and hyperlipidemia.T-test,chi-square test and Logistic regression analysis were used to analyze single factor,and multivariate Logistic regression was used to explore independent risk factors.Results: 826 cases were the object of study,450 patients with male,female 376 cases of patients,average age(33.9 + 7.6),the minimum age 18,the biggest age 45,334 patients with diabetes,hyperlipidemia,528 cases,456 cases of hypertension,overweight and(or),440 cases of obesity,smoking,369 cases.1.311 subjects were diagnosed with intracranial arterial stenosis,with a incidence of37.7%.Male: female =175:136,average(35.1 + 7.4)years old.No intracranial artery stenosis group male: female =275:240,average(33.2 + 7.7)years old.Among 313 patients with MS,the prevalence rate was 37.9%,among which male: female =166:147,average(35.3 + 7.2)years old.There were 513 patients without MS,male: female =284:229,average(33.1 + 7.8).The gender composition of the two groups was not statistically significant(P>0.05),and the age was significantly different(P<0.05).2.The chi-square test was adopted,and Pearson was 2=40.373,P=0.000<0.05,and the distribution of intracranial artery stenosis in patients with different amounts ofmetabolic diseases was statistically significant(P<0..05)the incidence of intracranial arterial stenosis increased with the increase of the number of combined metabolic diseases.3.Independent sample t test was adopted,and t=-2.035,P=0.042<0.05,the incidence of intracranial artery stenosis was higher in patients with smoking than non-smokers,and the difference was statistically significant.4.Independent sample t test was adopted,and t=-2.762,P=0.006<0.05,and the incidence of intracranial arterial stenosis was significantly higher in patients with family history than those without family history,and the difference was statistically significant.5.There were 313 cases in MS group,513 cases of non-ms group,50.8% of intracranial artery stenosis in MS group,and 29.6% of intracranial artery stenosis in non-ms group,with statistically significant difference(P<0.05).6,single factor analysis showed that age,smoking,family history,hypertension,diabetes,obesity,MS for youth of intracranial artery stenosis in patients with ischemic stroke risk factors(P < 0.05),gender,hyperlipidemia impact on young ischemic stroke patients with intracranial artery stenosis,no statistical significance(P > 0.05).Multivariate Logistic regression analysis showed that age,smoking,family history,MS,hypertension were independent risk factors(P<0.05),while diabetes and obesity were not independent risk factors(P BBB 0 0.05).The OR value of MS was 2.62,followed by smoking 1.65.Conclusion: MS is youth IAS important independent risk factor for ischemic stroke patients,but also important controllable factors,therefore,active prevention and treatment of metabolic syndrome,hypertension,in particular,is of great significance to preventing the young ischemic stroke,also offers a new target for the prevention and control of the young ischemic stroke.