The Study Of The Efficacy And Safety Of Different Doses Of Atorvastatin In The Treatment Of Atherosclerotic Cerebral Infarction In The Aged

Purpose:To compare the levels of high-sensitivity C-reactive protein(hs-CRP),homocysteine(Hcy),uric acid(UA),serum lipids,and NIHSS scores in elderly patients with atherosclerotic cerebral infarction,who are given different doses of atorvastatin.To investigate the efficacy of different doses of atorvastatin on regulating blood lipids,reducing inflammation and oxidative stress,and improving neurological function.To compare the levels of aspartate aminotransferase(AST),alanine aminotransferase(ALT),creatinine(Cr),and creatine kinase(CK)in patients with atherosclerotic cerebral infarction,who are given different doses of atorvastatin.To investigate atorvastatin the safety of liver,kidney and muscle.Method:A total of 124 elderly patients with atherosclerotic cerebral infarction admitted to the Department of Neurology,Affiliated Hospital of Qingdao University from 2016-11-01 to 2017-07-31 were selected.The subjects were randomly divided into two groups and were given different doses of atorvastatin(Lipitor).The conventional group was given atorvastatin 20 mg,and the fortified group was given atorvastatin 40 mg.Collect baseline data of all patients in detail,including: name,age,sex,hospital number,height(m),weight(kg),past history of disease,smoking history,medication history,etc.,and calculate BMI.Before and 10 days after treatment,relevant laboratory indicators were extracted,including: high-sensitivity C-reactive protein(hs-CRP),homocysteine(Hcy),and uric acid(Uric Acid,UA),Total Cholesterol(TC),Low-density Lipoprotein Cholesterol(LDL-C),High-density lipoprotein(HDL),Triglyceride(TG)Alanine Aminotransferase(ALT),Aspartate Transaminase(AST),Creatinine(Cr),Creatine kinase(CK).NIHSS scores for all patients by trained neurological physicians before and 10 days after treatment.Result:(1)There was no significant difference in the levels of LDL-C,TC,TG,and HDL before treatment in conventional groups and in intensive groups(P>0.05).In the conventional group,there was a significant difference in the levels of LDL-C,TC,TG,and HDL before treatment and after treatment(P<0.05).In the intensive group,there was a significant difference in the levels of LDL-C,TC,TG,and HDL before treatment and after treatment(P<0.05).There was a significant difference in the levels of LDL-C,TC,TG,and HDL after treatment in conventional groups and in intensive groups(P<0.05).The levels of LDL-C,TC,and TG after treatment decreased compared with that before treatment.The level of HDL increased after treatment compared with that before treatment.And the intensive group changed more clearly.(2)There was no significant difference in the levels of hs-CRP,Hcy,UA,and NIHSS score before treatment in conventional groups and in intensive groups(P>0.05).In the conventional group,there was a significant difference in the levels of hs-CRP,Hcy,UA,and NIHSS score before treatment and after treatment(P<0.05).In the intensive group,there was a significant difference in the levels of hs-CRP,Hcy,UA,and NIHSS score before treatment and after treatment(P<0.05).There was a significant difference in the levels of hs-CRP,Hcy,UA,and NIHSS score after treatment in conventional groups and in intensive groups(P<0.05).The levels of hs-CRP,Hcy,UA,and NIHSS score after treatment decreased compared with that before treatment.And the intensive group decreased more clearly.(3)There was no significant difference in the levels of ALT,AST,Cr and CK between the conventional group and the intensive group before treatment,between before treatment and after treatment in the conventional group,between before treatment and after treatment in the intensive group,and between the conventional group and the intensive group after treatment(P>0.05).Conclusion:Atorvastatin can reduce the levels of hs-CRP,Hcy,UA,TC,LDL-C,TG,and NIHSS scores in elderly patients with atherosclerotic cerebral infarction.It also can increase HDL levels.It can indicate that atorvastatin can reduce inflammation and oxidative stress,regulate blood lipids and improve neurological function.The effect of them was more obvious in the fortified group than that in conventional group.The effect was more significant.The levels of AST,ALT,Cr and CK were not increased in both groups,indicating that fortified group and conventional group both had good safety.