| Objective: Social and behavioral factors may impact phthalate exposure.However,available data are still limited.In this study,we assessed the associations between phthalate exposure and social and behavioral factors to investigate the impact factors.Phthalate exposure may also induce the change of blood pressure in animals.However,current studies have provided inconclusive evidence for an association between phthalate exposure and BP.Therefore,this study aims to examine the association between serum phthalate concentrations and BP in a Chinese population.Methods: We recruited study participates who presented themselves to the primary health care center of the Third Hospital of Hebei Medical University,from December 2014 to September 2015.Participates included609 adults between the ages of 18 and 55 years.The collect information included demographic information(age,gender,et al.),individual behavior(smoking,alcohol drinking,et al),dietary(consumption of beans,eggs,et al),health status by a questionnaire.Collected blood sample was used for the examination of 16 common PAEs levels through internal standard method.Several parameters of BP(systolic BP,diastolic BP,total cholesterol and triglyceride)were acquired from the physical examination results.Multivariate linear regression analysis was used to analysis social and behavioral factors affected phthalate exposure,and the relationship between phthalate exposure levels and parameters of BP.Results:1.DBP has the highest detection rate in the 16 phthalates,which was100%,the second two were DIBP and DMP,the detection rates were 89.7%and 79.8%,respectively.The detection rates of BMPP,DNOP and DEHP were between 60% and 80%,others had a lower detection rate than 60%.Thegeometric mean concentrations of the 6 phthalates which had the highest detection rates were 253.9ug/L,40.7ug/L,10.8ug/L,9.4ug/L,33.9ug/L and97.4ug/L,respectively.2.The associations between social behavioral factors and serum phthalates levels indicated that the consumption of eggs and barbecue were positively associated with DBP levels.Relative to that in the low-consumption group,DBP levels increased by 0.253(95% CI: 0.094,0.412)and 0.267(95% CI: 0.111,0.424)in median-and high-consumption groups of eggs,by 0.115(95% CI: 0.016,0.214)and 0.234(95% CI: 0.055,0.413)in median-and high-consumption groups of barbecue.Beer consumption was positively associated with DMP and BMPP.Relative to that in the group of no beer drinking,DMP levels increased by 0.201(95% CI: 0.005,0.396)in the high-consumption group of beer,BMPP levels increased by 0.239(95% CI:0.081,0.398)and 0.321(95% CI: 0.154,0.488)in low-and high-consumption groups of beer.BMI was positively associated with DMP,DBP and DEHP.The consumption of coffee was negatively associated with DMP and DIBP.3.The associations between serum phthalates and BP parameters indicated that BMPP exhibited a significant negative dose-related relationship with systolic BP.Relative to that in the reference group(the lowest-concentration group),systolic BP decreased by 2.858mmHg(95% CI:-5.470,-0.245)in the fourth quartile exposure group(the highest-concentration group).Otherwise,DMP exhibited a significant positive dose-related relationship with total cholesterol.Relative to that in the reference group,total cholesterol increased by 0.277mol/L(95% CI :0.081,0.474)in the fourth quartile exposure group(the highest-concentration group).These associations persisted even when considering exposure to multiple phthalates.Conclusion: In the social and behavioral factors,high frequencies in consumption of eggs,barbecue food and beer may increase phthalate exposure levels.And increased coffee consumption may decreased phthalateexposure levels.Phthalate exposure might decrease systolic BP and increase serum total cholesterol levels at the same time.However,the possible mechanism of phthalate-induced BP decrease remains unclear.Moreover,our findings need to be confirmed in further studies. |
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