Effects Of Humidifed High-flow Nasal Cannula Oxygen Therapy On The Patients With Type?Respiratory Failure

Objective: The purpose of this study was to determine the beneficial effects of humidifed high-flow nasal cannula oxygen(HFNC)on patients with type ? respiratory failure in comparison with conventional nasal cannula,facemask and noninvasive positive pressure ventilation(NPPV).Methods: 147 patients with type ? respiratory failure and without indication for immediate intubation in the department of respiratory medicine of the first affiliated hospital of China medical university From June 2016 to December 2017 were chosen as subjects.Oxygen therapy was divided into HFNC,conventional nasal cannula,facemask and NPPV.The primary outcomes were arterial blood gases,clinical respiratory parameters,patient comfort and the dilution of sputum,secondary outcomes included the proportion of patients intubated and mortality.Results: HFNC was associated with superior oxygenation,reduction of RR and P,and the dilution of sputum in compassion of conventional nasal cannula oxygen therapy,but there was no statistically significant difference in patient comfort.HFNC was associated with superior oxygenation,reduction of RR,and the dilution of sputum,and patient comfort,but no statistically significant differences in reduction of P,the proportion of patients intubated and mortality as compared to facemask oxygen therapy.In comparison with NPPV,HFNC was associated with superior patient comfort and inferior oxygenation performance,but no statistically significant differences in reduction of RR and P,the dilution of sputum,intubation rate and mortality.Conclusion: It may be reasonable to consider HFNC as an intermediate level of new type noninvasive respiratory support in between conventional therapy and NPPV.,with remarkable beneficial effects and good tolerance.