The Study Of Correlation Between High Risk Plaque Characteristics Of Coronary Artery By CT And Intra-plaque Hemorrhage Detected By MRI

Objective: Plaque rupture is the most common cause of acute coronary syndrome,accounting for about 70% of fatal acute myocardial infarction and / or sudden coronary heart disease deaths.As vulnerable plaque has the characteristics of occult occlusion,rupture of the sudden,therefore,how to early warning of vulnerable plaque screening of high-risk patients is a major health problem to be solved.Recently,it has been proposed that enhanced or swept cardiac magnetic resonance T1-weighted imaging can be used to characterize coronary atherosclerosis.However,the conventional acquisition methods and navigation gating currently used have several drawbacks.First,the anatomic coverage is limited to coronary arteries The recent section.Second,current spatial resolution is low and anisotropic.Third,the scanning time is long.Finally,as the background tissue in T1-weighted cardiac MRI is severely inhibited,bright blood images need to be acquired separately to provide an anatomic reference for identifying and locating the target lesion,further extending the overall scan time.This study will be to address the above limitations of traditional acquisition methods by applying the CATCH(Coronary Atherosclerosis T1 Weighted Representation and Integrated Anatomy Reference)imaging method.CATCH aims to provide the following: 1)three-dimensional full coverage;2)isotropic high spatial resolution(1.13 mm3);3)simultaneous acquisition of dark blood T1-weighted images and anatomical reference images.The purpose of this study is to explore the correlation between the two by comparing with the features of high-risk plaques observed in coronary CTA.Methods: CATCH sequence can obtain black blood T1-weighted images and bright blood anatomical reference images.Retrospective exercise correction to achieve 100%respiratory gating efficiency.The control group(n = 6)completed pre-enhancement and post-enhancement scans.Patients with stable angina(n = 24)completed an enhanced scan,and 24 of the eligible patients completed an enhanced scan.Before cardiac magnetic resonance,eligible coronary arteries were examined in all patients(n = 24).Two experienced analysts evaluated the plaques in the CTA and assessed whether they were at high risk of plaque(low CT,punctate calcification,napkin ringing,positive remodeling)who were unaware of the results of the magnetic resonance.Independent sample t-test,Fisher’s exact test,and Wilcoxon rank-sum test were used to perform intergroup comparisons of continuous variables,categorical variables,and ordinal variables,respectively.Whether the characteristics of high-risk plaques detected by CT are related to intra-plaque hemorrhage detected by MRI and which high-risk plaque characteristics are most related to intra-bladder hemorrhage,a 2×2 chi-square test of paired data will be used to analyze the categorical variables.All data are presented in mean ± SD(normally distributed data)or median and quartile range(non-normally distributed data)formats.For all analyses,both sides require a p-value of <0.05 to exclude zero Assumptions.Results: The analysis of vessel segments showed that there was no catch-sequence high-signal coronary artery plaque in the control group before and after the enhancement of all the blood vessel segments.In the test group,plaque hemorrhage occurred in 3vascular segment plain,and plaque hemorrhage occurred in 30 vascular segments.Patients with plaque bleed had more pronounced CTA high-risk plaque characteristics than patients without intraplaque plaque bleeding.Plaque hemorrhage and CTA detection of high-risk plaque characteristics were positively correlated.Conclusions: Plaque hemorrhage detected by magnetic resonance is associated with high-risk plaque characteristics detected by CT.