A Resting-state Functional Mri Study Of Abnormal Spontaneous Brain Function In Tinnitus Patients

Objective: Tinnitus is one of the three major symptoms of tinnitus,with complex etiology,so far there is no clear central nervous mechanism.By studying the resting-state functional magnetic resonance imaging(f MRI)of tinnitus patients,the changes of abnormal brain function in tinnitus patients were studied to explain why tinnitus can be accompanied by some negative emotions such as anxiety and depression at the same time and to explore the possible central nervous mechanism in the occurrence and development of tinnitus.Methods: In this study,according to strict inclusion criteria and exclusion criteria 7 tinnitus patients and 14 healthy people were enrolled.The patients with tinnitus were assessed with visual assessment scale(VAS),tinnitus handicap inventory(THI),Beck depression inventory(BDI)and Beck anxiety inventory(BAI)before the test.,and then carrying on the result analysis.All subjects underwent resting-state f MRI scanning.After multiple comparison and correction,comparison of imaging differences between the two groups by the amplitude of low-frequency fluctuations(ALFF)analysis,Regional homogeneity(Re Ho)analysis and degree centrality(DC)analysis.Results: Compared with the healthy people,the main brain regions with higher ALFF in tinnitus patients including bilateral precuneus and cingulate gyrus.The main areas of the brain with increased Re Ho including right middle frontal gyrus,right inferior frontal gyrus,right superior frontal gyrus,bilateral precuneus and cingulate gyrus.The main areas with increased DC including right superior temporal gyrus,bilateral middle temporal gyrus,bilateral middle frontal gyrus and bilateral superior frontal gyrus;The main brain regions with decreased DC including right hippocampus and left posterior central gyrus.Conclusion: Abnormal spontaneous brain function changes in many brain regions of tinnitus patients,involved in the default network and attention network abnormality.At the same time,the negative emotion and cognitive impairment of tinnitus patients were related to the spontaneous abnormal activities of partial marginal system,inferior frontal gyrus and middle temporal gyrus.The abnormal spontaneous brain function changes of the brain regions with abnormality of ALFF,Re Ho and DC of tinnitus patients may be one of the mechanisms of central nervous system in the occurrence and development of tinnitus.