Clinical Research On Comprison S-1 Concurrent Radiotherapy With Paclitaxed Plus Cisplation Concurrent Radiotherapy In Locally Advanced Unresectable Esophaygeal Cangcer Patient

Objectives To observe the obiective response rate,toxicity,median survival time as well as 1 year survival rates of S-1 with paclitaxed plus cisplation and concurrent radiotherapy for locally advanced unresectable esophageal cancer.Methods 94 patients of locally advanced cancer hospitalized in Tang shan People's Hospital form March,2012 to February,2017 were retrospected.Divide these patients into two groups,36 were treated with S-1 and concurrent radiotherapy,58 were treated with paclitaxed plus cisplation and concurrent radiotherapy.All the patients were treated with three-dimensional conformal radiotherapy(1.8-2Gy/time and the total dose was 56-64Gy).The group of S-1 and concurrent radiotherapy : S1(40-60 mg/m2/time,po d1-14 q3w);the group of paclitaxed plus cisplation and concurrent radiotherapy:TP(paclitaxel 40mg/m2 + cisplatin 20mg/m2,d1,8,15,22,29,36)or(paclitaxel 135-175mg/m2 + cisplatin 75mg/m2,q3 w,2 cycles).Results 1.The obiective response rates was 83.33% in the S-1 concurrent radiotherapy group and 77.58% in the paclitaxed plus cisplation concurrent radiotherapy group,?2=39.191,P=0.000,and two groups were statistically significant(P<0.05);2?1 year survival rates of the two groups were 74.7% and 74.1% respectively,and there was no significant difference(P>0.05);3?In the radiation esophagitis,radiation pneumonitis and myelosuppression,the group of S-1 and concurrent radiotherapy group were lower than the paclitaxed plus cisplation and concurrent radiotherapy group;but in the gastrointestinal reaction the group of S-1 and concurrent radiotherapy group were higher than the paclitaxed plus cisplation and concurrent radiotherapy group,all these we can found the statistic difference(P<0.05).Conclusion The group of S-1 and concurrent radiotherapy has higher survival rate compared with the group of paclitaxed plus cisplation and concurrent radiotherapy in the treatment locally advanced unresectable esophaygeal cancerr;In the radiation esophagitis,radiation pneumonitis and myelosuppression,the group of S-1 and concurrent radiotherapy group were lower than the paclitaxed plus cisplation and concurrent radiotherapy group;but in the gastrointestinal reaction the group of S-1 and concurrent radiotherapy group were higher than the paclitaxed plus cisplation and concurrent radiotherapy group,however all patients were well-tolerated;In the median survival time and the 1 year survival rates,the two groups were no difference.