Effect Of TOMATIS High And Low Audio Conversion Training On Cognitive And Stress Disorder In Patients With Breast Cancer After Chemothreapy

Objectives To explore the effects of TOMATIS high and low audio conversion training on cognitive function and post traumatic stress function in patients with breast cancer after chemotherapy,with an aim to provide a basis for finding more effective and simple rehabilitation nursing methods.Methods 120 breast cancer patients with chemotherapy-related cognitive impairment and post-traumatic stress disorder after chemotherapy were recruited from the People's Hospital of Tangshan from October 2016 to September 2017.The patients were divided into experiment group1(n=40),experiment group2(n=40)and control group(n=40)by random table method.The control group was given the routine nursing during chemotherapy,experiment group2 received conventional music(unprocessed audio)based on the routine nursing during chemotherapy,and experiment group1 received TOMATIS auditory training(music with high and low audio audio processing).It includes 2 hosts equipped with touch control panel(The back of the host is distinguished by different color marks.The green flag is the high and low conversion audio host,and the red audio is the unprocessed host.),2 wireless signal transmitters that were matched with hosts,and several wireless headphones possessing bone conduction and air conduction technology.It allowed for training on numerous patients at the same time.The music contents and procedures were designed by the research group and neurocognitive experts at the university of marseille in France for the characteristics of diseases and treatment processes.It included Mozart series of music and Gregoria hymns.The operator changed the music program in accordance with the preset order.Both groups were performed at the same time each day,starting at the second chemotherapeutic cycles.A total of 4 phases,21 days apart.The patient was interacted for 5 days consecutively,4 times a day.They were assessed with Rivermead behavioral memory test seconf edition(RBMT-II),Behavioral Assessment of Dysexecutive Syndrome(BADS)and Post-traumatic Stress Disorder Self-rating Scale(PTSD-SS)before and after intervention,and observed the effects of the intervention.All data were input into Excel and the results were analyzed by SPSS19.0 statistical software after verification.The measurement data were expressed as mean�standard((x|-)�s).All experimental data were compared by variance test,t test and multilevel model test before and after intervention.Difference with P<0.05 was deemed as statistically significant.Results 1 Results of cognitive function evaluation of three groups.1)There was no significant difference in MoCA score among the three groups before intervention(P>0.05).Comparison of MoCA scores after intervention among 3 groups: The effect of different treatments and time on MoCA score in patients with breast cancer chemotherapy was statistically significant(P<0.05),the TOMATIS high and low audio conversion training group was significantly better than the other groups and the longer the intervention time was,the more significant the MoCA score was.2)Results of memory function evaluation of three groups.There was no significant difference in MoCA score among the three groups before intervention(P>0.05).Comparison of RBMT-II scores after intervention among 3 groups: The influence of different treatments of RBMT-II score was statistically significant(P<0.05),the intervention time of RBMT-II score has no obvious difference(P>0.05).3)Results of executive function evaluation of three groups.There was no significant difference in BADS score among the three groups before intervention(P>0.05).Comparison of BADS scores after intervention among 3 groups: The effect of different treatments and time on BADS scores was statistically significant(P<0.05),and the longer the intervention time,the more obvious the BADS score increased.2 Results of Post traumatic stress disorder function evaluation of three groups.There was no significant difference in PTSD-SS score among the three groups before intervention(P>0.05).The effects of different treatments and time on the PTSD-SS score were statistically significant(P<0.05).Conclusions 1 TOMATIS high and low audio conversion training can significantly improve the cognitive function of breast cancer patients with chemotherapy-related cognitive impairment.2 TOMATIS high and low audio conversion training can remarkably reduce post-traumatic stress disorder in patients with breast cancer chemotherapy.