Analysis Of Clinical Characteristics Of Cervical Squamous Cell Carcinoma And Cervical Adenocarcinoma

Objective:This article selected 2469 cases of cervical cancer patients from January 2007 to December 2016 in NO.2 Hospital of Jilin University,including 2168 cases of cervical squamous cell carcinoma and 301 cases of cervical adenocarcinoma.Their clinical features were analyzed retrospectively.The differences in the clinical characteristics of cervical squamous cell carcinoma and cervical adenocarcinoma provide a reasonable basis for the choice of treatment options to cervical cancer patients,and provide more reference value for the identification of cervical squamous cell carcinoma and adenocarcinoma.Methods:The preliminary statistics of cervical squamous cell carcinoma and cervical adenocarcinoma were performed through the EXCEL form.The clinical manifestations,age,menopause status,FIGO staging,preoperative examination(HPV,TCT),treatment program(whether to retain the ovary),pathological results(differentiation,vascular invasion,lymph node metastasis,ovarian metastasis,myometrial invasion depth,etc.),survival and other related factors of cervical squamous cell carcinoma and cervical adenocarcinoma were retrospectively analyzed.SPSS 21.0 system was used for statistical analysis of data.Kaplan-Meier survival analysis and Log-rank test were used for survival analysis and influencing factors analysis,and survival curves were drawn.The statistical result P<0.05 was considered statistically significant.Result:1.The overall age of cervical cancer was 19-82 years old,and the average age of onset was 48.557±9.4977 years,mainly concentrated in 36-55 years old.Among them,the average age of onset in cervical squamous cell carcinoma group was 48.731±9.4848 years old.The average age of the cervical adenocarcinoma group was 47.307±9.5128 years old,and there was no significant difference in the mean age of onset between the two pathological types,and there was no significant difference compared with the overall age of onset(P>0.05).2.The main clinical manifestation of cervical cancer is vaginal bleeding.There is no significant difference between cervical squamous cellcarcinoma and adenocarcinoma(P>0.05).In the clinical manifestations of vaginal discharge,the proportion of cervical adenocarcinoma is higher than that of cervical scale.In the cancer group,the difference was statistically significant(P<0.05).3.The correct rate of preoperative diagnosis in cervical squamous cell carcinoma group was higher than that in cervical adenocarcinoma group(P<0.05).The positive rate of lymph node in cervical squamous cell carcinoma group was higher than that in cervical adenocarcinoma group(P<0.05).4.For cervical cancer screening,the sensitivity of only TCT examination is about 80.6%,the sensitivity of HPV-DNA alone is 91.8%,and the sensitivity of TCT combined with HPV-DNA detection is as high as 98.1%.5.The effect of neoadjuvant chemotherapy on the survival of patients with different pathological types of cervical cancer was not significantly different(P>0.05).6.The three-year disease-free survival rates of stage?,stage?A,stage?B,stage?and above were 97.6%,85.4%,77.9% and 28.6% respectively,the difference was statistically significant(P<0.05).The 5-year survival rates were 92.6%,58.2%,40.4% and 20.3%,respectively,with significant differences(P<0.05).The 3-year survival rates of cervical squamous cell carcinoma and adenocarcinoma were 91.5% and 87.4%,respectively,and the 5-year survival rates were 77.5% and 54.8%,respectively,with statistical significance(P<0.05).7.The degree of pathological differentiation,FIGO stage,depth of myometrial invasion,vascular invasion,lymph node metastasis,and ovarian metastasis are the main risk factors affecting the prognosis of cervical cancer patients(P<0.05),age,menopausal status,retention Ovarian condition had no significant effect on the prognosis of cervical cancer(P>0.05).Menopausal status,pathological differentiation,FIGO stage,depth of muscle infiltration,lymph node metastasis,retention of ovary,and metastasis of ovary were risk factors affecting the prognosis of cervical adenocarcinoma(P<0.05),but the degree of pathological differentiation,FIGO stage,vascular invasion,depth of myometrial invasion,and lymph node metastasis were risk factors affecting the prognosis of cervical squamous cell carcinoma(P<0.05).Conclusion:1.The onset age of cervical cancer is mainly concentrated in 36-55 years old.There is no significant difference in the average age of onset between cervical squamous cell carcinoma and adenocarcinoma,both showing a younger trend of development.2.Cervical cancer most of the clinical manifestations of non-specific,mainly for irregular vaginal bleeding and vaginal discharge,cervical squamous cell carcinoma and cervical adenocarcinoma in vaginal irregular blood flow was no significant difference,while cervical adenocarcinoma is more prone to vaginal discharge liquid.3.HPV-DNA detection combined with TCT detection is more accurate and sensitive than HPV-DNA detection and TCT detection alone.The sensitivity of HPV or TCT of cervical adenocarcinoma was lower than cervical squamous cell carcinoma.Although both results were negative,it should be further examined for patients with high suspicion of cervical lesions.4.It is relatively safe for young and early patients of cervical squamous cell carcinoma to retain the ovaries.The ovarian metastasis rate of cervical adenocarcinoma is higher than cervical squamous cell carcinoma.5.Neoadjuvant chemotherapy had no significant effect on the survival of cervical squamous cell carcinoma and adenocarcinoma,but some patients could recover the surgical opportunity,increase the surgical resection rate,reduce the chance of tumor dissemination during surgery.6.The prognosis and survival period of cervical adenocarcinoma are worse than cervical squamous cell carcinoma.Patients with high-risk recurrence factors should be followed closely.