Preliminary Study Of Clinical Features And Survival Analysis Of Papillary Thyroid Carcinoma In Pediatrics And Adolescents

Objective:To study the clinicopathologic characteristics,prognosis,and survival analysis of papillary thyroid carcinoma in children and adolescents.Method:The study subjects were 94 children and adolescents all treated by thyroid surgery due to papillary thyroid carcinoma,from Jan.2000 to Jan.2013.The criteria is as following:?1?all patients under 21 years old at diagnosis;?2?all patients diagnosed as thyroid papillary carcinoma postoperatively;?3?the original data and follow-up data of the cases complete.The clinicopathological characteristics and prognostic factors were analysed,and survival analysis was described in comparision.Results:94 PTC patients were stratified into prepubertal?n=15?and pubertal?n=79?groups.The prepubertal group tended to involve bilateral gland,be mulifocality,and progress with extrathyroid extension.Risk factors for prognosis were lateral cervical lymph node metastasis?p<0.001?,lung metastasis?p<0.001?,and therapeutic I¹³¹?p<0.001?.Survivalswithout reintervention at 3 and 5 years were,respectively,89.2%and81.0%.Conclusion:1.The prepubertal group tended to involve bilateral gland,be mulifocality,and progress with extrathyroid extension.2.Risk factors for prognosis were lateral cervical lymph node metastasis,lung metastasis,and therapeutic I¹³¹.3.recurrence occurred frequently within3 years,and children in the prepubertal group were more likely to recur.4.Children and adolescents,with lateral cervical metastasis and lung metastasis but without I ¹³¹ therapy,should be intensively treated and closely monitored.