Clinical Trial Of "Hexue Rougan Recipe" In Treating Chronic Hepatitis B Liver Fibrosis(Syndrome Of Liver Depression And Spleen Deficiency)

Objective:Observe the efficacy and safety of "He Xue Rou Gan Prescription" in the treatment of chronic hepatitis B liver fiber(liver stagnation and spleen deficiency syndrome).Methods:Inclusion of patients with hepatic fibrosis at the beginning or after treatment of chronic hepatitis B in Xinjiang Uygur Autonomous Region from June 2016 to July 2017.The transient elasticity imaging LSM was≥F2.TCM differentiation was associated with liver depression and spleen deficiency.The patient’s wishes were divided into control group(entecavir monotherapy)and test group(entecavir combined with Xuerougan recipe).The changes of LSM,APRI,FIB-4,and blood routine,liver function,and renal function before and after treatment were recorded.At the same time TCM symptom scores.Result:1.After 24 weeks of treatment,the total effective rates of the test group and the control group were 86.67% and 60.00%,respectively,with statistical differences(P<0.05).2.Comparison of TCM Symptom Scores:(1)After 24 weeks of treatment,the test group was lower than the control group,P<0.05;(2)After 24 weeks of treatment in both groups,the total score of TCM symptoms was lower than baseline,P<0.05;(3)Comparison of the total score difference of TCM symptoms before and after treatment between the two groups of patients,the test group was higher than the control group,P<0.05;3.Non-invasive liver fibrosis index:(1)After 24 weeks of treatment in both groups,LSM was lower than baseline,P<0.05;The APRI score in the test group was lower than baseline at 24 weeks,P<0.05;(2)Comparing the differences of LSM in two groups,the LSM of the test group was higher than that of the control group,P<0.05;4.Safety indicators: After 24 weeks of treatment,there was no significant difference in baseline liver function and renal function between the two groups(P>0.05).Conclusion: "He Xue Rou Gan Prescription" has good efficacy and safety in treating liver fibrosis of chronic hepatitis B with liver depression and spleen deficiency.