The Relationship Between Renalase And LVT?EF?BNP In Patients With CKD

Objective:In recent years,In our country has been a steady rise in economic environment,with the improvement of people material life condition and the change of lifestyle,the incidence of hypertension and heart and vascular disease and mortality rate increased significantly,has become a threat to people's life in China under current era of the no.1 "murderers".A large amount of data and clinical practice to prove: compared with patients with other diseases,chronic kidney disease in patients with hypertension,the incidence of cardiovascular disease(CVD)is relatively high,and difficult to control,so we need to find new alternative therapies,to control high blood pressure patients with chronic kidney disease(CKD),delay the progress of the cardiovascular disease,kidney disease.Studies have confirmed that Renalase mainly by renal proximal convoluted tubules of synthesis and secretion,when kidney function was seriously damaged,the level of plasma Renalase a downward trend,catecholamine concentration increasing,blood pressure increases,This will be a new option for patients with chronic renal disease with refractory hypertension.Beginning from the study of clinical,collected in different periods of patients with chronic kidney disease(CKD)of plasma and their Renalase levels have been measured,and the left ventricular wall thickness,EF,BNP,RI values,to find out the correlation between them.Methods:Among the 75 patients with chronic renal disease in the renal department of Qingdao municipal hospital from January 2016 to March 2017,15 patients with CKD(1-5)were collected according to the international eGFR estimation standard.The serum Renalase protein level was detected by ELISA in 75 patients.The heart and renal ultrasound of the 75 patients included: left ventricular thickness and EF,BNP,and RI values.The patient was included in the patient's elbow venous blood to detect Serum creatinine(SC)and urine.Grain nitrogen(Urea nitrogen,the UN),Uric acid,Uric acid,UA),Blood calcium,Blood calcium,BC),potassium(serum potassium,SP),albumin(albumin,A),b-type natriuretic peptide(B-type natriuretic peptide,BNP)levels,measured in patients not taking Blood pressure drugs of the same time when the systolic pressure,diastolic Blood pressure.After data collection complete,compare different period the plasma Renalase levels of patients with chronic kidney disease(CKD),left ventricular(LV)wall thickness and ejection fraction(EF),b-type natriuretic peptide(BNP),the correlation of RI.Results:1.All patients successfully completed the extraction of venous blood,blood pressure measurement,no omission,withdrawal and death.2.chronic kidney disease(CKD1)The average:Serum creatinine(71.09)umol/L?Urea nitrogen(5.59)mmol/L?Uric acid(421.72)umol/L?Blood calcium(2.43)mmol/L?potassium(3.89)mmol/L?albumin(42.76)mmol/L?Systolic blood pressure(120.75)mmHg?Diastolic blood pressure(70.5)mm Hg?Renalase(182.11)ng/L?B-type natriuretic peptide(76.1)pg/ml?Ejection fraction(62)%?Left ventricular wall thickness(40.9)mm?Resistance index(0.6,0.61)3.chronic kidney disease(CKD2)The average:Serum creatinine(106.09)umol/L?Urea nitrogen(10.93)mmol/L?Uric acid(425.19)umol/L?Blood calcium(2.25)mmol/L?potassium(3.89)mmol/L?albumin(34.69)mmol/L?Systolic blood pressure(147.6)mmHg?Diastolic blood pressure(77.8)mm Hg?Renalase(171.27)ng/L?B-type natriuretic peptide(180.26)pg/ml?Ejection fraction(58.4)%?Left ventricular wall thickness(43.18)mm?Resistance index(0.7,0.7)4.chronic kidney disease(CKD3)The average:Serum creatinine(125.15)umol/L?Urea nitrogen(10.69)mmol/L?Uric acid(420.2)umol/L?Blood calcium(2.27)mmol/L?potassium(4.44)mmol/L?albumin(35.86)mmol/L?Systolic blood pressure(134.33)mmHg?Diastolic blood pressure(73)mm Hg?Renalase(169.83)ng/L?B-type natriuretic peptide(160.63)pg/ml?Ejection fraction(60)%?Left ventricular wall thickness(42.33)mm?Resistance index(0.62,0.61)5.chronic kidney disease(CKD4)The average:Serum creatinine(320.97)umol/L?Urea nitrogen(23.78)mmol/L?Uric acid(536.65)umol/L?Blood calcium(2.47)mmol/L?potassium(4.21)mmol/L?albumin(40.11)mmol/L?Systolic blood pressure(151.25)mmHg?Diastolic blood pressure(80)mm Hg?Renalase(184.25)ng/L?B-type natriuretic peptide(280.75)pg/ml?Ejection fraction(62)%?Left ventricular wall thickness(46.68)mm?Resistance index(0.71,0.71)6.chronic kidney disease(CKD5)The average:Serum creatinine(522.4)umol/L?Urea nitrogen(22.13)mmol/L?Uric acid(481.81)umol/L?Blood calcium(2.26)mmol/L?potassium(4.95)mmol/L?albumin(36.59)mmol/L?Systolic blood pressure(138.33)mmHg?Diastolic blood pressure(79.33)mm Hg?Renalase(139.15)ng/L?B-type natriuretic peptide(278.1)pg/ml?Ejection fraction(52.83)%?Left ventricular wall thickness(53.9)mm?Resistance index(0.74,0.74)Conclusions:With chronic kidney disease patients with eGFR decreased,plasma Renalase levels showed a trend of gradual decline,the patient's blood pressure,left ventricular wall thickness,b-type natriuretic peptide,RI increased,reduced ejection fraction,further proves the plasma Renalase for cardiovascular and kidney is the protective.