CT-guided Percutaneous Irreversible Electroporation Ablation In The Treatment Of Renal Cell Carcinoma:Clinical Application And Research

Objective To investigate the preliminary effect and safety of irreversible electroporation(IRE)for renal-cell carcinoma.Methods Seven patients with renal-cell carcinoma having no indication of operation were enrolled.Procedures were performed under general anesthesia.The therapeutic efficacy was evaluated according to response evaluation criteria in solid tumors of WHO.Results All procedures were completed successfully.The average tumor volume was(12.41±13.92)cm3(0.9-40.8 cm3).The average procedure time were(88.63±37.49)minutes(42-174 minutes).The average procedure rounds were(7.13±1.25)times(6-9)times.The average number of pulses were(1710.00±466.60)times(750-2240)times.No sever complications occurred during and after IRE procedure.Enhanced CT and/or MRI scans were performed immediate post procedure,1 month and 3 months after procedure.All lesions showed hypodense/low signal ablation areas without enhancement and the peritumoral tissue were undamaged.The post procedure 3 months dynamic image showed complete response(CR)in all 8 lesions.Conclusion CT-guided percutaneous IRE is safe and effective in patients with renal-cell carcinoma and can be a promising alternative way to treat renal-cell carcinoma with no indication of operation.