Correlation Study Of Von Willebrand Factor And Systemic Autoimmune Disease

Objective:This paper is aim to explore the correlation between von Willebrand factor(vWF)and systemic autoimmune diseases(AID).Methods:This is a retrospective analysis,which of our hospital between January 2016 and April 2017 hospital of systemic autoimmune disease,autoimmune diseases,AID),136 cases of patients.There are including rheumatoid arthritis(RA,n= 68),systemic lupus(SLE,n= 28),connective tissue disease(CTD)/undifferentiated connective tissue disease(UCTD)/mixed connective tissue disease(MCTD)are total of 12,Sjogren's syndrome(SSc,n= 8),systemic sclerosis(SS,n= 3),Adult onset Still's disease(AOSD,n= 1),dermatomyositis(DM)/multiple myositis(PM)are total of 5,ANCA associated vasculitis(ANCA-association vasculitis,n= 5),the overlap syndrome(n=8).By analyze the patients' general information,complications(anemia,interstitial pneumonia,cerebral infarction)and laboratory test(PLT,CRP,ANA and ESR).The Distribution of vWF multimer in plasma was detected by Western Blot,and the content of vWF antigen(vWF:Ag)in plasma was detected by ELISA.Results:1.The incidence of systemic AID in women was higher than that in men(female:male = 5-6:1),and the onset age was mostly between 50 and 80 years old(72.6%).RA was the largest in all patients,with a total of 68 cases(50%).Second,there were 29 cases(21.3%)with SLE.2.About 96%of patients with systemic AID had higher vWF multimer Distribution in plasma than the normal standard mixed plasma.Different general information(including sex,age,fixed number of year,complications,etc.),laboratory tests(including the PLT,ESR,C3,CRP,IgG,ANA,CCP antibody resistance,etc.),different diseases,and the different categories of systemic AID patients of plasma content of vWF multimer Distribution by difference analysis,results show that the p>0.05).3.About 96%of patients with systemic AID had more vWF:Ag in plasma than the normal standard mixed plasma.Different materials(including sex,age,fixed number of year,complications,etc.),laboratory tests(including the PLT,ESR,C3,CRP,IgG,ANA,CCP antibody resistance,etc.),disease types are grouped,and the different categories of systemic AID patient's plasma vWF:Ag content difference analysis.The results of correlation analysis between groups of general data showed that the correlation analysis of age group(r= 0.279)and age group(r= 0.173)was p<0.05.Other general data were grouped for correlation analysis p>0.05.Laboratory examination,according to the results of correlation analysis of grouping C3 group(H=2.356)and CRP group(Z = 2.165)correlation analysis p<0.05,the rest of the laboratory examination correlation analysis different groups p>0.05).In single-factor analysis,the significant factor complement C3,CRP,age and years of onset were included in multivariate linear regression analysis as independent variables.The regression coefficient of years of onset was 8.640(2.436,14.844),p<0.05.The difference analysis of plasma vWF:Ag content in different diseases showed p<0.05,among which the rank and mean value of RA were 88.49.vWF:Ag is related to vWF multimer Distribution(r= 0.495),p<0.01.Conclusion:The content of vWF multimer Distribution and vWF:Ag in plasma increased in 96%of patients with systemic AID,and these were positively correl-ated.The history of systemic AID was positively correlated with the increase of vWF:Ag in plasma of systemic AID.We showed the positive regression,suggesting that the history of systemic AID was an independent factor for the increase of vWF:Ag in plasma of systemic AID by multivariate linear regression analysis.Age was also associated with increased plasma vWF:Ag content.The increase of vWF:Ag in plasma of patients with systemic AID was negatively correlated with complement C3 and CRP.vWF:Ag in different systemic AID plasma was involved in all cases,and RA was the most associated with the increase.