Prevalence Of Hyperhomocysteinemia And Its Determinants In Rural Hypertensive Patients In Eastern China

Objective The purpose of this present study were to investigate the prevalence of hyperhomocysteinemia and explore its determinants in rural hypertension individuals in Eastern China.Methods A total of 17179 hypertensive individuals were enrolled from rural areas of Lianyungang,Jiangsu province and Anqing,Anhui province.Standard epidemiological questionnaire investigation(demographic characteristics,occupation and living conditions,smoking status,drinking status,diet,medication history and disease history),physical examination(blood pressure,height,weight,waist circumference and hip circumference)and laboratory methods(tHcy,blood routine,urine routine,fasting blood glucose,blood lipid)were conducted to collect information.Hyperhomocysteinemia was defined as a homocysteine(tHcy)concentration?10?mol/L.Multivariable linear regression and logistic regression analyses were performed to determine the factors with homocysteine or hyperhomocysteinemia.Results In the present study,17179 participants were recruited in the final analyses,6954were male and 10225 were female.The study population had a mean age of(64.5±7.4)years.The tHcy concentrations of study population were(13.6±7.1)?mol/L and 77.9%had hyperhomocysteinemia.After adjusting for group,center,age,sex,BMI,blood pressure,smoking,drinking,physical activity,glucose,serum lipid,tHcy concentrations were positively associated with male(female vs male,?=-2.78,SE=0.17,P<0.001),age(per 1 year age increment:?=0.17,SE=0.01,P<0.001),BMI(per 1 kg/m~2 BMI increment:?=0.07,SE=0.02,P<0.001),current smoking(current smoking vs never smoking,?=0.66,SE=0.18,P<0.001),total cholesterol(per 1 mmol/L total cholesterol increment:?=0.24,SE=0.05,P<0.001),triglyceride(per 1 mmol/L triglyceride increment:?=0.20,SE=0.04,P<0.001),low density lipoprotein(per 1 mmol/L low density lipoprotein increment:?=0.12,SE=0.05,P=0.028);and negatively associated with current drinking(?=-0.65,SE=0.17,P<0.001),physical activity(high vs low,?=-0.61,SE=0.17,P<0.001).Consistently,a higher prevalence of hyperhomocysteinemia was positively associated with male(female vs male,OR=0.31,95%CI:0.27-0.36,P<0.001),age(per 1 year age increment:OR=1.09,95%CI:1.08-1.09,P<0.001),BMI(per 1 kg/m~2 BMI increment:OR=1.04,95%CI:1.03-1.05,P<0.001),total cholesterol(per 1 mmol/L total cholesterol increment:OR=1.11,95%CI:1.07-1.16,P<0.001),triglyceride(per 1 mmol/L triglyceride increment:OR=1.03,95%CI:1.00-1.06,P=0.043),low density lipoprotein(per 1 mmol/L low density lipoprotein increment:OR=1.08,95%CI:1.04-1.12,P<0.001);and negatively associated with physical activity(high vs low,OR=0.81,95%CI:0.72-0.91,P<0.001),glucose(per 1 mmol/L glucose increment:OR=0.97,95%CI:0.96-0.99,P=0.006).Conclusions The prevalence of hyperhomocysteinemia in rural hypertension population in East China is high.Men,age,BMI,smoking,total cholesterol,triglyceride and low density lipoprotein were positively associated with homocysteine concentrations,whereas physical activity and glucose were negatively associated with homocysteine levels.