Application Of Adaptive Support Ventilation In Patients With Acute Respiratory Distress Syndrome

Objective Acute respiratory distress syndrome is a common clinical critically disease in ICU patients,which is a life-threatening form characterized by severe hypoxemia and severe respiratory distress symptoms.The clinical mortality rate is as high as 40%-50 %,and the prognosis is poor.This disease often causes great financial pressure on patients and their families.Mechanical ventilation is an effective clinical treatment of acute respiratory distress syndrome.Currently recommended lower tidal volumes and higher positive end-expiratory pressure ventilation mode,to achieve the ventilation program is often achieved with P-SIMV mode.With the progress of research,lower tidal volumes and higher positive end-expiratory pressure mode also has its drawbacks,so gradually explore the new breathing pattern to deal with acute respiratory distress syndrome,improve patient lung oxygenation status,correct hypoxia,so as to achieve the purpose of improving patient prognosis.Methods This study has the characteristics of randomization and prospectiv,so as to ensure the credibility of the findings.The study selected adequate sample size from Intensive Care Unit of the Hefei First People's Hospital headquarters and Binhu Hospital at the same time.Firstly,the subjects were selected to meet the criteria set by Berlin in 2012 for acute respiratory distress syndrome.Patients with severe acidosis,severe shock and death within a short period of time after admission were excluded.Then,the subjects were divided into a P-SIMV group receiving lower tidal volumes and higher PEEP ventilation mode,and an ASV group received adaptive support ventilation randomly.The parameters of each group were set respectively.The respiratory rate,tidal volume,p H,oxygen partial pressure,partial pressure of carbon dioxide,oxygen saturation,oxygenation index,duration of mechanical ventilation,ICU stay and so on were collected before and after ventilation for 48 hours.Finally,analysis and compare the data differences between the two groups.Results A total of 60 patients were selected for the study,30 in both groups.There were no differences in the age,sex and APACHE II scores between the two groups.There was no significant difference in the VT,RR,p H,PO2,PCO2,SO2,PO2 / Fi O2 between the two groups when on the machine(P> 0.05).Compared 48 h after ventilation with before mechanical ventilation: ASV group of RR,p H,PO2,PCO2,SO2,oxygenation index was statistically significant(P <0.05).P-SIMV group of RR,tidal volume,PO2,SO2 and oxygenation index was significantly higher(P <0.05).The comparison between the two groups after 48 h mechanical ventilation: p H,PCO2,PO2 / Fi O2 statistically significant difference(P <0.05).There was a significant difference between the two groups in the duration of mechanical ventilation and the length of ICU stay.Conclusions ASV mode and P-SIMV mode can improve respiratory oxygenation status and improve patient's prognosis in the treatment of patients with ARDS.Both ARDS patients can benefit from these two modes.And in some indicators,ASV mode better results in shortened the duration of mechanical ventilation and ICU stay.Moreover,the setting of the mode parameter is relatively simple,the human-machine cooperation is better,and the patient is more comfortable which can be one of effective methods for treating ARDS.