| Objective:To compare and analyze the efficacy and toxicities of esophageal cancer treated with different radiotherapy doses of synchronous chemotherapy,and provide radiation dosimetry basis for clinical treatment of tumors and assessment of prognosis.Methods : Totally 28 patients with newly diagnosed esophageal cancer who were pathologically confirmed by our department,were divided into A(60-64 Gy,high dose group)and B(50Gy,low dose group)according to the principle of "randomization".The two groups of patients were treated with Siemens ARTISTE intensity modulated radiotherapy system targeting area mapping,radiotherapy field design and radiotherapy plan implementation,chemotherapy using TP program(DOC 75 mg / m2 d1,DDP 30 mg / m2 d1-3).And in the radiotherapy and chemotherapy before and after 1 weeks to improve ultrasound endoscopy,chest CT and other related tests.The curative effects,side effects and imaging changes of the two groups were compared respectively.Results:(1)Short-term curative effect: The effective rates of high-dose and low-dose groups are 93.75% and 41.67%,respectively,with statistical significance(P <0.05).(2)The changes of EUS test results: The lesion infiltration level and peripheral lymph node regression in the high dose group were more obvious,which indicated that the short term effect was dominant(P <0.05);(3)side effects: two groups of patients with bone marrow suppression,radioactive esophagitis and other toxic side effects no significant difference(P> 0.05).Conclusion:Synchronous radiotherapy and chemotherapy in the treatment of patients with advanced esophageal cancer,the short-term efficacy of the high-dose radiotherapy group was good,and did not increase the side effects of radiotherapy. |
PDF Full Text Request