Efficacy And Discontinuation Reasons Of Dapoxetine In The Treatment Of Lifelong Premature Ejaculation

Objective: To evaluate the efficacy of dapoxetine hydrochloride and its discontinuation reasons.Method: 126 patients with lifelong premature ejaculation of in outpatient department were recruited from Jan.2017 to Jun.2017.Each of them were asked to finish a detailed questionare including basic demographic information(e.g.name,age,height,weight,education status,marriage income,etc.),Premature ejaculation profile(PEP),and International Index of Erectile Function-5(IIEF-5).The patients received a dapoxetine prescription(30 mg on demand)1-3 hours before sexual life.Follow-up was conducted after 1,3,6 month.PEP,Whether discontinuation and reasons of discontinuation were recorded.Results: PEP score of continuted patients at 1,3,6 months increased significantly from 4.87±2.72,4.80±2.81,4.69±2.36 to 9.43±2.59,10.16±2.37,10.72±2.21 after the treatment(P<0.05).5(4%)patients rejected dapoxetine from the beginning,and their reasons were high cost and afraid of addiction to dapoxetine,the rates of which were 3(60%)and 2(40%)respective.121(96%)patients accepted the treatment,of which 64(53%)patients insisted on the treatment.57(47%)patients discontinue the treatment within 6 month,and their reasons were inefficient 2(3.5%),effect below expectation 18(31.6%),high cost 19(33.3%),side effect 4(7.0%),losing follow-up 4(7.0%),other treatment 5(8.8%)and cure 5(8.8%).Patients whose age >=40,or income <100 thousand yuan,or education beneath the bachelor degree were more inclined to discontinue the treatment than that of age...