The Principle Of Diagnosis And Treatment Of Autosomal Dominant Polycystic Kidney Disease(Report Of 152 Cases)

ObjectiveThe clinical data of autosomal dominant polycystic kidney disease(ADPKD)were statistically analyzed to further improve the understanding of the diagnosis and treatment of ADPKD.MethodThe clinical data of 152 patients with ADPKD who were treated at the Provincial Hospital of Shandong Province from 2005 to 2016 were collected,Summarize and analyze the general conditions,clinical manifestations,auxiliary examinations,surgical methods,postoperative recovery of the collected cases.First,the clinical data are normally tested.Statistical description of measurement data that is normally distributed is expressed as mean±standard deviation..For single factor analysis,if the measurement data meets the normal distribution and homogeneity of variance,the t-test is used.Bilateral P<0.05 was statistically significant.ResultAmong the 152 patients,the incidence rate of males was slightly higher than that of females,and the main age was over 40 years old.The main symptoms at the time of treatment included pain,hematuria,and repeated fever.There were 137 cases undergoing ultrasonic examination and 128 cases undergoing CT examination.Only one case was examined by MRI.130 cases were surgically treated with decompression of polycystic kidney disease.129 cases of postoperative pathology were diagnosed as polycystic kidney disease,and one case diagnosed as polycystic kidney disease with cystic kidney cancer.Statistical analysis of glomerular filtration rate(GFR),hypertension,and renal volume before and after surgery.GFR and kidney volume was significantly improved compared with the preoperative(P<0.05),and blood pressure were not significantly improved before surgery(P>0.05).Conclusion1.ADPKD is a benign disease,but there are still no methods that can be completely cured.Men are slightly higher than women.Most patients with ADPKD can be diagnosed by B-ultrasound and CT.Pathological examination after the diagnosis is necessary.2.Most ADPKD patients have obvious clinical symptoms and their kidney function has been compromised,delaying the best treatment time.Patients with a family history of polycystic kidney disease should be examined regularly in youth and intervened in time.3.At present,there is still no uniform standard for the treatment of ADPKD,and surgical or conservative treatments are mostly based on the clinical symptoms of the patients and the impairment of renal function.The vast majority of patients eventually require renal replacement therapy.4.A very small number of patients with ADPKD will have a malignant tumor of the kidney.The pathological findings after surgery cannot be diagnosed.After surgery,follow-up observations should be strengthened to prevent recurrence.