Study On The Relationship Between Febrile Seizures And Electrolytes

Objective:Analyze the relationship between biochemical detection of sodium,calcium,and potassium levels and febrile seizures to provide guidance for clinical diagnosis and/or prevention of febrile seizures;explore the relationship between arterial blood gas and biochemical tests for sodium,calcium and potassium ions for clinical purposes Provide guidance on the selection of the auxiliary examination method..Methods:A total of 584 children were selected from the Children's Hospital of Dalian from October 2016 to October 2017 in strict accordance with the pre-designed inclusion and exclusion criteria,Which consistent with the previous history of febrile seizures,the incidence of febrile seizures due to respiratory tract infection in 154 cases of children admitted to the convulsive recurrence group;consistent with no previous history of febrile seizures,the cause of febrile seizures due to respiratory tract infection admission 82 cases of children as the convulsive first group;consistent with the history of previous febrile seizures,the respiratory tract infection led to fever but no seizures in93 children as past seizure group;in line with no previous history of febrile seizures,this time there is no febrile seizures,260 cases of children hospitalized for fever due to respiratory tract infection were Simple respiratory infection group.The convulsive recurrence group and the convulsive first group were named convulsive seizure group,Past seizure group and Simple respiratory infection group were named no seizure group;convulsive recurrence group + past seizure group was named as convulsive historygroup,first attack group and simple respiratory tract The infected group was named as without convulsion history group.For the convulsive seizure group(convulsant recurrence group + convulsive first group): Collect general clinical data(age,gender,family history,convulsive seizures,seizure temperature and heat duration),and take arterial blood and veins within 48 hours of convulsive seizures Blood determines potassium,sodium and calcium levels.For the no seizure group(previous seizure group+ simple respiratory infection group): general clinical data(age,gender,family history and previous convulsions)were collected,and venous blood was measured within 3days of heat and fever to determine potassium,sodium,and calcium ions.SPSS22.0software package for the collected data for statistical analysis.The rank sum test was used to compare whether there was difference in the temperature and the heat history when the seizure occurred in the convulsant recurrence group and the convulsive first group.The rank sum test was used to compare the temperature and heat history of seizures in both male and female groups.The chi-square test was used to compare the temperature and heat history of seizures in different age groups.Using chi-square test to analyze the relapse of seizure and family history.Using multi-factor analysis of variance analysis of four groups of potassium,sodium and calcium levels.The relationship between arterial blood gases and biochemical detection of sodium,calcium and potassium ions was investigated by t test.Results:1.In the convulsive seizure group,the age of children was mainly ranging from 6months to 3 years(61.9%).The male gender was the most common,accounting for63.6%.2.In the convulsive seizure group,89.4% of children suffered from seizures within24 hours of fever and 55.1% of children who experienced seizures within 8 hours of fever;97% of those children whose body temperature rose to above 38 ? during seizures.There was no statistical difference in the temperature and heat history between seizures in convulsant recurrence group and convulsive first group(p> 0.05).There was no statistical difference in the temperature and heat history between seizures inmale and female children(p> 0.05)There was no statistical difference in the temperature(?2=0.299,p>0.05)and the heat history(?2=1.252,p>0.05)in the age group with seizures.3.The correlation between recurrent febrile convulsions and family history was not statistically significant(?2=2.766,p>0.05).4.The potassium ion concentration(4.67 ± 0.86 mmol / L)in convulsive seizure group was significantly higher than that in no seizure group(4.43 ± 0.59 mmol / L)(p <0.05);There was no significant difference in potassium ion between convulsive history group(4.58 ± 0.77mmol/L)and without convulsion history group(4.50 ±0.68mmol/L)(p> 0.05).5.The sodium ion concentration(134.51 ± 0.19 mmol / L)in convulsive seizure group was lower than that in no seizure group(140.67 ± 0.17 mmol / L),the difference was statistically significant(p <0.05);The sodium ion concentration(137.23± 0.23 mmol / L)in convulsive history group was lower than that in without convulsion history group(137.95 ± 0.18 mmol / L),the difference was statistically significant(p <0.05).6.The calcium concentration in convulsive seizure group was(2.31 ±0.24 mmol / L)lower than that in no seizure group(2.38 ± 0.17 mmol / L,the difference was statistically significant(p <0.05);The calcium concentration in convulsive history group(2.30 ± 0.28 mmol / L)was lower than that of without convulsion history group(2.39 ± 0.12 mmol / L),the difference was statistically significant(p <0.05),and the two factors interacted significantly(F=8.066,p=0.005).7.Biochemical determination of potassium(4.73 ± 0.90 mmol / L),sodium(135.85 ± 3.44 mmol / L),calcium(2.35 ± 0.10 mmol / L)ion concentrations were higher than those measured by arterial blood gas method,potassium(4.44 ±1.02 mmol / L),sodium(133.18 ± 2.58 mmol / L)and calcium(1.16 ± 0.11 mmol /L),the differences were statistically significant(p <0.05).Conclusion:1.The heat stroke and temperature of each convulsive episode in children withfebrile seizures were not related to the history of febrile seizures,gender,and age.2.There may be some correlation between elevated serum potassium and febrile seizures,and more studies are needed to prove it further.The decrease of serum sodium and serum calcium is closely related to the and febrile seizures,and the relationship between calcium ion and febrile seizures may be more closely related.3.Electrolyte test results should be based on biochemical analyzer test results,supplemented by blood gas analyzer test results.