The Clinical Features And Pathological Characteristic Of Angiomyofibroblastoma Of Female Reproductive Organs

Purpose:Angiomyofibroblastoma(AMF)as the source of mesenchymal benign tumor,clinical rare,both men and women can come on,common in the female reproductive system of childbearing age,the most common in female genital,followed by the place such as cervical,vaginal and groin.For clinical medical examination found the mass after seeing a doctor,no specific symptoms and signs,easily misdiagnosed as other soft tissue mass,it is difficult to diagnosis preoperatively,biopsy and postoperative pathology is the only means of diagnosis.In this paper,combined with clinical cases and related literature to explore the female reproductive organs vascular muscle fiber mother cell tumor of the clinical features,pathological characteristics,diagnosis and treatment methods and prognosis,in order to help clinician to this kind of disease to do further understanding.Methods:A retrospective analysis in January 2012 to October 2017 in dalian hospital affiliated to dalian medical university and dalian medical university first affiliated hospital make a diagnosis and give treatment of 10 cases of female genital organs vascular muscle fiber mother cell tumor in patients with clinical data.Summarize the basic information of patients,and analyze the clinical features and pathological features,diagnosis methods,treatment and prognosis of the patients.Clinical features include age,symptoms,signs,location,tumor size,preoperative imaging examination and tumor markers,etc.Pathological features include general features,microscopic features,intraoperative frozen and histopathological immunohistochemistry;The diagnosis and treatment method is mainly the postoperative pathology.Postoperative follow-up was performed to observe the prognosis of patients.Results:10 patients with vascular muscle fiber mother cell tumors of the average onset age(49.90 + 7.62),no obvious clinical symptoms,individual patient may due to the mass images,life can be different at different parts of the course to the tumor size is differ,women in the place such as the vulva,the vagina,the cervix,pelvic;The imaging examination is non-specific,and the tumor can be seen as isoechoic,hypoechoic or mixed echo light,and the blood flow signal can be seen.No abnormalities were observed in tumor markers;Gross tumor are single,I can provide multiple,section pink or brown,soft,bag piece solid or cystic or solid,borders,the microscopic cells Feng Fu District and sparse area distribution is alternant sex,tumor tissue by significantly the lumen of small,thin wall and the expansion of blood vessels,blood vessels around the visible acidophilic round or spindle group around the tumor cells,tumor were edema,myxoid matrix,etc.,nuclear fission as rare.All 10 patients underwent partial complete resection.8 cases were followed up,and the median follow-up time was 37 months without recurrence.Conclusion:vascular muscle fiber mother cell tumor in childbearing age women,the main location for female vulva and vagina,occurred in cervical and pelvic rare,male visible in the scrotum,testicular,spermatic cord or groin area.Vascular muscle fiber mother cell tumor pathogenesis is unclear,the main consideration for local damage,inflammatory stimulation and combination of estrogen and other reasons,to induce endothelial to the muscle fiber mother cell differentiation and tissue around the tumor formation abnormal muscle fiber mother cell proliferation.The clinical manifestation and imaging of angiomyocytoma in female reproductive organs were not specific,which was not significant for clinical diagnosis.At present,biopsy pathology and postoperative pathology are still considered to be the only method for the diagnosis of angiomyoblastoma.Vascular muscle fiber mother cell tumor is easily misdiagnosed as vestibular big gland cyst,abscess and lipoma,and other interstitial fibroblasts-source of muscle fiber mother cell tumor in clinical manifestations and the microscopic pathology are similar,characteristic of differential diagnosis mainly depends on pathology and immunohistochemistry.The treatment was mainly performed with surgical excision,and the general prognosis was good.The number of cases in this study is limited,and the clinical need to continue to summarize and study vascular myofibroblastoma.