Analysis Of TCM Syndrome Distribution And Its Related Factors In Patients With Postoperative Non-small Cell Lung Cancer

Objective To explore the distribution pattern of TCM syndromes in patients with postoperative non-small cell carcinoma,and further analyze the related factors influencing syndrome differentiation of TCM to provide important clinical application value for TCM classification and prognosis of NSCLC and provides evidence for clinicians to improve TCM syndrome differentiation and drug use.Methods The subject adopts a prospective epidemiological research method,collects basic information,radiotherapy and chemotherapy and clinical symptoms of 288 non-small cell lung cancer patients according to the inclusion criteria and exclusion criteria,and fills in a pre-designed clinical observation table for TCM symptoms of non-small cell lung cancer.The syndrome differentiation criteria for syndrome-type judgments,and then summed up the non-small cell lung cancer recovery period TCM syndrome pattern,and use statistical software analysis of patient age,pathological type,pathological stage,Karnofsky score,chemotherapy,prognosis and tumor markers Relevance of material and syndrome distribution.Results(1)The distribution of TCM syndrome in patients with convalescence in lung and spleen two deficiency most of non-small cell lung cancer,accounting for 26.7% of the total,followed by Qi and yin deficiency,spleen deficiency type,yin deficiency,phlegm heat in the lung,qi stagnation and blood stasis,respectively accounted for 20.8%,17.4%,13.2%,12.5%,9.4%,the distribution of after the analysis of TCM syndrome type was statistically significant(P<0.05);(2)The three different age groups of youth,middle age,and old age were mainly based on deficiency of lung and spleen,followed by deficiency of Qi and Yin and deficiency of dampness of spleen and spleen.After analysis,the age range of different patients did not appear in the distribution of TCM syndrome types.Statistical significance(P>0.05),considered that age had no effect on TCM classification of patients with postoperative non-small cell lung cancer;(3)The TCM syndrome types of adenocarcinoma and squamous cell carcinoma in patients with non-small cell lung cancer were the most common in lung and spleen two,followed by Qi Yin two deficiency syndrome.After analysis,the distribution of adenocarcinoma and squamous cell carcinoma in TCM syndromes was not statistically significant(P>0.05),indicating that two different TNM types of squamous cell carcinoma and adenocarcinoma do not affect the distribution of TCM syndromes;(4)The most common I patients with TCM syndrome type in lung and spleen deficiency syndrome in two,accounting for I period of 31.2%,followed by qi stagnation and blood stasis,yin deficiency,spleen dampness,Qi Yin deficiency and phlegm heat in the lung;II period with lung spleen deficiency syndrome and two common,accounted for II period of 31.8%,followed by spleen dampness,Qi and yin deficiency two phlegm heat obstructing the lung and the yin deficiency and qi stagnation and blood stasis syndrome is the least;IIIa to two Qi and yin deficiency syndrome,accounted for 31.6% of IIIa,followed by the lung and spleen deficiency syndrome,two phlegm heat in the lung,spleen deficiency,yin deficiency,qi stagnation and blood stasis.After analysis,there was statistical significance in the distribution of TCM syndromes in different pathological stages(P<0.05),that is,different pathological stages affect the distribution of TCM syndromes;(5)Karnofsky score 40-70 points between the distribution of TCM Syndromes of phlegm dampness of spleen deficiency more common,followed by phlegm heat in lung syndrome,lung spleen two deficiency,qi stagnation and blood stasis,yin deficiency,Qi and yin deficiency syndrome in two;more than 70 points to two more,lung and spleen deficiency syndrome,followed by two Qi and yin deficiency syndrome,yin deficiency spleen deficiency phlegm,blood stasis,phlegm heat in lung syndrome.After analyzing,there was statistical significance in the distribution of TCM syndromes in different stages(P<0.05);(6)The main empirical gemcitabine and pemetrexed group before chemotherapy with TCM syndrome type of spleen dampness,qi stagnation and blood stasis,phlegm heat in the lung after chemotherapy,TCM syndrome type distribution mainly in the lung and spleen deficiency syndrome and two of two Qi and yin deficiency syndrome,spleen dampness,phlegm heat in the lung and qi stagnation and blood stasis were significantly lower.After analysis,the distribution of TCM syndromes in gemcitabine group and pemetrexed group was statistically significant(P<0.05),and it could be considered that chemotherapy regimen had an effect on the distribution of TCM syndromes;(7)The serum levels of carcinoembryonic antigen,cytokeratin 19 and squamous cell carcinoma antigen were statistically significant in the distribution of TCM syndromes(P<0.05).CEA has significant differences in syndromes of qi stagnation,blood stasis,and sputum obstruction in different TCM syndrome differentiation types.It has significant statistical significance with lung and spleen deficiency syndrome,spleen deficiency and dampness,yin deficiency heat,and qi and yin deficiency syndrome.(P<0.05);CYFRA21-1 was more markedly elevated with deficiency of Qi and yin and yin deficiency.There was statistically significant difference between lung and spleen deficiency,yin deficiency and sputum fever,spleen deficiency,and qi stagnation and blood stasis.Sex differences(P<0.05);SCC increased lung and spleen deficiency syndrome significantly,compared with spleen deficiency dampness,yin deficiency internal heat statistically significant difference(P<0.05),indicating that tumor markers and TCM classification Correlation;(8)The distribution characteristics of TCM syndromes in patients without metastasis was two in lung and spleen deficiency,Qi and yin deficiency two,followed by the internal heat due to yin deficiency and phlegm heat in the lung,spleen dampness,qi stagnation and blood stasis;had recurrence and metastasis of TCM syndrome type distribution is characterized by a deficiency with phlegm and qi stagnation and blood stasis,followed by two lung and spleen deficiency,deficiency of both qi and Yin,yin deficiency,phlegm heat in lung syndrome.After analysis,the difference in the distribution of TCM syndrome types was statistically significant(P<0.05).The proportion of spleen deficiency,phlegm dampness type and qi stagnation and blood stasis type increased in patients with recurrence and metastasis compared with those without recurrence and metastasis.The chi square test(P<0.05)showed statistically significant difference.Conclusions(1)Two in lung and spleen deficiency,deficiency of Qi and yin deficiency syndrome based and non small cell lung cancer patients with TCM syndrome type distribution,followed by deficiency of phlegm dampness,yin deficiency,phlegm heat in the lung,qi stagnation and blood stasis type;(2)The distribution of TCM syndromes in patients with postoperative non-small cell lung cancer is not affected by age and pathological type.The influence of TNM stage,Carson score,chemotherapy and prognosis and prognosis can provide a basis for clinical workers to improve the level of TCM differentiation and prescriptions;(3)The TCM Syndromes of recurrence and metastasis are mainly spleen deficiency,phlegm dampness syndrome and qi stagnation and blood stasis syndrome,which indicates that phlegm dampness and blood stasis are the important factors that affect tumor recurrence and metastasis.