A Meta-analysis:Relationship Between HBV,HCV And Risk Of Cholangiocarcinoma

[Objective]Adopt Meta-analysis method to comprehensively analyze the relationship of cholangiocarcinoma risk associated with HBV and HCV infection.[Method:]According to the basic principles of evidence-based medicine,we use a computer to retrieve papers and conference papers regarding analyzing the relationship of Cholangiocarcinoma risk associated with HBV and HCV infection publically published all over the world from 2000-2017.The databases retrieved include Pubmed,Embase,The Cochrane Library,CNKI,WF,VIP and CMB.For references meeting the requirements,Meta analysis is then carried out to the information extracted by using Revman5.3 software provided by International Evidence-based Medicine Collaboration Website.Adopting Random effects model to estimate the combined effect and Calculating the odds ratio(OR)and 95%Confidence Interval(CI),Finally use the funnel figure to evaluate the bias analysis.[Results]In total,26 articles met the inclusion standard,of which 14 were from China,6 from the United States,3 from Korea,2 from Japan and 1 from Italy;There were 21 reports on intrahepatic cholangiocarcinoma and 13 on extrahepatic cholangiocarcinoma.According to NOS(Newcastle-Ottawa),the quality rating scale was used to evaluate the methodology of literature collection,in which 11 articles with 7 points,8 papers with 8 points and 4 articles with 9 points were collected.The results of the analysis are as follows:①Four combinations’OR are 4.14、3.76、1.58、1.75 of HBV correlated with ICC,HCV with ECC,HBV with ECC,UCV with ECC,②In Asia group and Europe group,the OR of HCV correlated with ICC were 3.24 and 4.18;HCV correlated with ICC were 1.43 and 2.40;HBV correlated with ICC were 4.69 and 2.88.[Conclusion]1.The relationship between HBV,HCV and cholangiocarcinoma risk is positive.2.There are similar risk for cholangiocarcinoma between the two different types of hepatitis virus infection.3.The risk of intrahepatic cholangiocarcinoma was always higher than that of extrahepatic cholangiocarcinoma,whether from HBV infection or HCV infection.4.There are regional differences in the incidence of cholangiocarcinoma caused by hepatitis virus infection.From the aspect of HCV infection,the risk of hepatitis virus infection in Europe and America is higher than that in Asian countries,whether from the point of view of ICC or ECC.However,from the aspect of HBV infection,the risk of intrahepatic cholangiocarcinoma is higher in Asian countries than that in American countries,while the study of extrahepatic cholangiocarcinoma lacks original data.