Comparison Of Dosimetry In Body Gamma Knife And IMRT Of Primary Liver Carcinoma

Objective:Analysis of primary liver cancer in the body gamma knife and intensity modulated radiotherapy(IMRT)dosimetric characteristics of the plan,two sets of plans in the organ protection(OARs)and liver volume differences in low dose region size,provides the reference for the clinical choice of optimal radiotherapy plan.Methods:The CT scan images of 15 patients with primary liver cancer in the oncology department of the Second Affiliated Hospital of Hunan Normal University were selected.The image is transmitted to the OURQGD type gamma knife wTPS99 treatment plan and the Precise series IMRT Mnonoca program system.The body gamma knife and IMRT plan were designed to give the prescribed dose of the target area(PTV)40Gy(5 Gy/8 times per day,1 times a day),and the equivalent biological dose was 60Gy.The dose coverage of the 2 target areas,the average dose and volume of the normal liver tissue,the maximum dose near the endanger organ(Dmax),the target area conformability(CI)and the homogeneity(HI)of the target organs were compared,and the advantages and disadvantages of the 2 radiotherapy modes were analyzed.Results:1.Comparison of body gamma knife and IMRT plans,the target area average dose(Dmean)and the maximum dose(Dmax)in the target area had statistically significant difference,gamma knife plan is far higher than the IMRT plan,Comparison of the two plans,the conformability(CI)and homogeneity(HI)in the target area had no statistically significant difference,and the IMRT plan had advantages.Comparison of the two plans,the average irradiated dose(MDTNL)of the normal liver had no statistically significant difference.Comparison of the two plans of the normal liver,the V5 and V30 had statistically significant difference.The V5 of the body gamma knife plan has the advantage,and the IMRT plan V30 has the advantage.The comparison of the two plans of V10 V20 and average irradiated dose(MDTNL)had no statistical significance difference.2.There were statistically significant differences between the two plans in gastric,duodenal and right renal,and the body gamma knife plan had a better protective effect.There was no statistically significant difference between the two plans in spinal and left renal.Conclusions:1.In the cases of locally advanced primary liver cancer with single focus less than 5cm,the body gamma knife can obtain higher target dose than IMRT,But its conformability and homogeneity should be further optimized.2.The body gamma knife can reduce the incidence of RILD compared with IMRT,and has better protective effects on organs such as stomach,duodenum and right kidney.