Investigation Of The Relationship Between Fat-soluble Vitamins (Vitamin A,D,E) And The Severity In Children Patients With Sepsis

Objective:To investigate the relationship between fat-soluble vitamins(vitamin A,D,E)and the severity in children patients with sepsis.Methods:Ninety-one children with sepsis diagnosed in the first affiliated Hospital of Hunan normal University from November 2017 to March 2018 were studied prospectively.The levels of vitamin A,D and E in serum of children with sepsis were measured by high performance liquid chromatography(HPLC)or tandem mass spectrometry(LC-MS).The patients were divided into appropriate groups and unsuitable groups.The sex,age,onset time,antibiotic use time,serum free calcium,white blood cell count(WBC),C-reactive protein(CRP),procalcitonin(PCT),affected organs,PCIS score,SOFA score,septic shock,invasive mechanical ventilation were recorded and compare.The end point is 28 daysResults:1.Ninety-one children with sepsis,appropriate groups of vitamin D were seventy-one,unsuitable groups were twenty.There were significant differences in age,free calcium level,affected organs,PCIS score,SOFA score and septic shock between the two groups(P<0.05),there was no significant difference in sex,onset time,antibiotic use time,WBC,CRP,PCT,invasive mechanical ventilation between the two groups(P>0.05).2.Eighty-two children with sepsis,appropriate groups of vitamin A were eleven,unsuitable groups were seventy-one,there were significant differences in invasive mechanical ventilation between the two groups(P<0.05),there was no significant difference in sex,age,onset time,antibiotic use time,serum free calcium,WBC,CRP,PCT,affected organs,PCIS score,SOFA score,septic shock between the two groups(P>0.05).3.Ninety-one children with sepsis,appropriate groups of vitamin A were sixty-three,unsuitable groups were twenty-eight.There were significant differences in CRP,septic shock between the two groups(P<0.05),there was no significant difference sex,age,onset time,antibiotic use time,serum free calcium,WBC,PCT,affected organs,PCIS score,SOFA score,invasive mechanical ventilation between the two groups(P>0.05).Conclusion:1.The vitamin D levels in children with sepsis are related to the severity of the disease.The lower the level of vitamin D,the more severe the disease may be;2.There was no significant correlation between the levels of vitamin A.E in children with sepsis.