Event-related Desynchronization And Synchronization During Cued Continuous Performance Tasks In Patients With Mild Traumatic Brain Injury

Objective: Mild Traumatic Brain Injury(m TBI)is one of the common injuries in the clinical nervous system.This study analyzed the neuropsychological and neurophysiological characteristics of mild traumatic brain injury,explored the characteristics and neural mechanisms of attention disorder in m TBI patients.Methods: Twenty patients with m TBI and twenty healthy controls underwent the Mini-Mental State Examination(MMSE)and a cued continuous performance task(AX-CPT).Neuropsychological,behavioral,and electroencephalogram(EEG)data were collected and analyzed.The neuropsychological characteristics and Event-related desynchronization and synchronization(ERD/ERS)of m TBI patients and healthy controls were collected and analyzed.Results:(1)MMSE results: The total MMSE score in the m TBI group(28.00 ± 1.18)was lower than that in the healthy control group(29.20 ± 1.03),and the attention and calculation score in the m TBI group(3.95 ± 0.59)was lower than that in the healthy control group(4.65 ± 0.48),the above differences are statistically significant(P<0.05).There was no significant difference in orientation,memory,recall and verbal between the m TBI group and the healthy control group(P>0.05).(2)AX-CPT results: Hitting number in the m TBI group(66.76 ± 3.26)was lower than that in the healthy control group(69.11 ± 1.41),and reaction time in the m TBI group(532.57 ± 129.53ms)was longer than that in the healthy control group(412.61 ± 116.26ms).The number of errors of omission in the m TBI group(3.23 ± 3.27)was more than that in healthy controls(0.89 ± 1.42).The above differences were statistically significant(P<0.05).There was no significant difference in the number of false errors between m TBI and healthy controls(P>0.05).(3)ERD/ERS results: During the 0–200ms after the Go stimulus onset,αERS in the m TBI group was lower in the following brain regions than in the healthy control group,and the difference was statistically significant(P>0.05): the left entorhinal,the left fusiform,the left superiortemporal,the left middletemporal,the left inferiortemporal,the left transversetemporal,the left supramarginal,the left precentral,the left postcentral,the left parahippocampal,the left superiorparietal,the right rostralanteriorcingulate,the right medialorbitofrontal,the right parahippocampal,the right precentral,the right postcentral,the right transversetemporal。During the 600–800ms after the Go stimulus onset,the αERD in the m TBI group was lower in the right inferiortemporal than in the healthy control group,and the difference was statistically significant(P>0.05).During the 800–1000ms after the Go stimulus onset,the αERD in the m TBI group was lower in the following brain regions than in the healthy control group,and the difference was statistically significant(P>0.05): the left precentral,the right superiorfrontal,the right caudalmiddlefrontal,the right postcentral,the right supramarginal.During the 200–400ms after the Go stimulus onset,the βERS of m TBI group was less than the healthy control group in the following brain regions,and the difference was statistically significant(P>0.05): the right lingual,the right pericalcarine。During the 400–600ms after the Nogo stimulus onset,the αERD in the m TBI group was lower in the following brain regions than in the healthy control group and the difference was statistically significant(P>0.05): the left superiorparietal,the right superiorparietal,the right inferiorparietal。During the 600–800ms after the Nogo stimulus onset,the αERD in the m TBI group was lower in the following brain regions than in the healthy control group and the difference was statistically significant(P>0.05): the left cuneus,the left precuneus,the left pericalcarine,the left posteriorcingulate,the right cuneus,the right precuneus,the right isthmuscingulate,the right posteriorcingulate。During the 800–1000ms after the Nogo stimulus onset,the αERD in the m TBI group was lower in the following brain regions than in the healthy control group and the difference was statistically significant(P>0.05): the left cuneus,the left precuneus,the left medialorbitofrontal,the left precentral,the left postcentral,the left superiorparietal,the left transversetemporal,the right paracentral.There were no significant differences in the Nogo-αERS and Nogo-βERD/ERS between the m TBI group and the control group.Conclusion: Patients with m TBI exhibited impairments in Sustained attention and reaction speed,maybe due to the impairments of the distribution of attention resources and the pre-activation of neural networks reduced.