| Objective: According to the general clinical data and laboratory test indicators of patients to explore the new-onset of type 2 diabetes with ketosisprone patients clinical features.At the same time,according to research whether the clinical indicators included in the research on the correlation between ketosis-prone,analysis of diagnostic value of each index of the new-onset of type 2 diabetes with ketosis-prone.Methods: A total of 124 newly diagnosed type 2 diabetic patients admitted to department of endocrinology,Liuzhou people's hospital from February2016 to January 2018 were randomly divided into two groups: 48 cases of ketosis-prone type 2diabetes(KPD-T2 DM group,observation group),76 cases of type 2 diabetes(T2DM group,control group).The observation group was male: 30 cases,female: 18 cases;control group male: 47 cases,female: 29 cases.Inclusion method:(1)Diagnosis of diabetes according to the1999 ADA diagnostic criteria and classification criteria: 1.fasting venous blood glucose FPG ? 7.0mmol/L(126mg/dl),fasting is defined as at least8 hours without calorie intake;2.diabetes symptoms,and any time plasma glucose ? 11.1mmol/L(200mg/dl);3.OGTT 2 hours of plasma glucose? 11mmol/L(200mg/dl);two consecutive review of one of the three positive,were diagnosed with diabetes.(2)The onset time of less than 12 months,and before that the study did not receive drugs or insulin and otherhypoglycemic hypoglycemic treatment method.(3)Patients with acute check urine ketone bodies,arterial blood gas analysis,islet cell antibody?insulin antibody and glutamic acid decarboxylase antibody and antibody were negative.The urine ketone body positive patients for new-onset of type 2diabetes with ketosis-prone(KPD-T2 DM group,observation group),the urine ketone body negative patients for new-onset of type 2 diabetes(T2DM group,control group).Respectively,two groups of patients were grouped comparative study,which according to the PH value blood gas analysis(PH? 7.35)and a disturbance of consciousness,clear obvious ketoacidosis patients.(4)According to antibody test results: insulin antibody,islet cell antibody,glutamic acid decarboxylase antibody,excluding any one of the three antibody positive patients;Among them,glutamic acid decarboxylase antibody ? 1.0U / ml is defined as the antibody positive[26].All patients were measured on the day of admission,such as height,weight,blood pressure,interrogation of family history,smoking history and other clinical data,at the same time pumping venous blood to check random blood sugar.Fasting blood samples were taken at 6:30 on the second morning,fasting blood glucose,Triglycerides(TG),Total cholesterol(TC),Low density lipoprotein(LDL),Glycosylated hemoglobin(Hb A1c),Serum uric acid,24-hour urine was collected,measuring 24-hour urinary trace protein.On the third day after admission,oral glucose tolerance test,islet function test and fasting blood glucose(FPG),120 minutes blood glucose(2h PG),fasting C-peptide(FCP)and 120 minutes C peptide(2h CP)were recorded.After one after another to improve the liver B-ultrasound,cervical vascular ultrasound and other inspection items.Results:(1)An independent sample t test of 2 groups of data was carried out by using SPSS22.0 statistical software.The results showed that all the 2groups of middle-aged men were the main body of the disease,the incidence of the observation group and the control group were 62.5%(30/48)and 61.8%(47/76)(P<0.05);The observation group was comparative younger than that of in control group(P<0.05);The systolic blood pressure in the observation group was lower than that in the control group,and the blood pressure was relatively stable(P=0.000<0.05);The fasting blood glucose in the observation group was higher than that in the control group(P=0.000<0.05);The observation group had a higher level of random blood glucose than the control group(P<0.05);The serum uric acid in observation group was higher than that in control group(P<0.05);120 min C-peptide levels in the observation group were lower than those in the control group(P<0.05).(2)Logistoics regression analysis was used to analyze the distribution of clinical features in two groups of patients.It was found that the systolic blood pressure,family history,Hb A1 c,fasting blood glucose and blood uric acid,has obvious relevance.And the difference was statistically significant(P<0.05).Analysis using ROC curve analysis included clinical measurement data in the study on the diagnosis of ketosis diagnostic value of newly diagnosed patients with type 2 diabetes mellitus,including age,duration,systolic blood pressure,glycosylated hemoglobin,fasting blood glucose,medical treatment,random blood glucose OGTT experiment: fasting blood glucose,2 hour postprandial blood glucose,stimulation of C peptide P values were less than 0.05,there was statistical significance.Conclusions: The observation group compared with control group,the clinical features of the patients in the observation group: middle-aged male patients for the onset of the subject;male patients than in female patients with more blood uric acid metabolism significantly;the observation group and the control group were combined with a variety of metabolic disorders,includingthe observation group of blood uric acid increased more significantly;the observation group patients in the early stages of the disease showed different degrees of elevated urinary albumin.High levels of Hb A1 c,fasting blood glucose at the time of diagnosis,blood uric acid is an important risk factor in the observation group.Ketosis-prone type 2diabetes' Hb A1 c level and blood glucose level,medical treatment when the random blood glucose level and OGTT tests: fasting blood glucose and 2 hour postprandial blood glucose level,stimulation of c-peptide levels in higher value to assist the diagnosis of. |
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