| Objective:Adjuvant treatment of Biomimetic electrical stimulation were used in moderate and severe Intrauterine Adhesions after Transcervical resection of adhesion.Through observe the recovery of uterine cavity after three months by second hysteroscop,according to form of uterine cavity endometrial thickness?menstrual recovery and other aspects to assess the clinical efficacy of biomimetic electrostimulation for TCRA postoperative reviscosity,explore the moderate and severe uterine cavity Sticky TCRA effective prevention of adhesions and recurrence.Methods:Gathered between October 2015 and September 2017 in the our Hospital,was diagnosed as having moderate to severe intrauterine adhesions by hysteroscopy,and 70 patients undergoing TCRA under hysteroscopy were successfully collected.Using prospective analysis and research methods,patients were divided into two groups according to the principle of random grouping: observation group(Bioelectric stimulation group)and control group(35 cases each).Both groups were placed intrauterine support balloon,intrauterine injection of medical sodium hyaluronate,intrauterine circular intrauterine device,and oral estrogen and progesterone sequential therapy;observation group was added to the treatment of the control group.Biomimetic electrical stimulation.All patients received oral estrogen in the third month of the 15 th day to review the transvaginal ultrasound and record the thickness of the endometrium;record the menstruation after three months;the menstrual period after the third trimester was clean and 3-5 days after the hospitalization and review Hysteroscopic parallel ring surgery to record the uterine cavity morphology.The thickness of the endometrium,the recovery of menstruation,and hysteroscopy were used to investigate the intrauterine adhesions after 3 cycles of treatment.Results:(1)The uterine cavity recovery was reviewed 3 months after the operation: After the treatment,the hysteroscopy scores of all patients in the two groups were reduced 3 months after surgery;the overall cure rate of the biomimetic electrical stimulation group was 45.7%,and the improvement rate was 42.8%.The total effective rate was 88.6%;the total cure rate in the control group was 28.6%,the improvement rate was 51.4%,and the total effective rate was 85.7%.The total cure rate of bionic electrical stimulation was significantly higher than that of the control group.There was no significant difference between the two groups(P>0.05).The bionic electrical stimulation improvement rate was lower than that of the control group.There was no significant difference between the two groups(P>0.05);biomimetic electrical stimulation The group's effective rate was higher than that of the control group.There was no significant difference between the two groups(P>0.05).(2)Changes in the thickness of the endometrium: The endometrium thickness was 6.74 ± 0.82 mm after treatment in the bio-electrical stimulation group,and the intimal change range was 0 to 3 mm,with an average increase of 1.51 ± 0.57 mm,of which 26 patients were treated intraoperatively.Membrane thickness ?7mm,2 cases of intima without change;control group after treatment intimal thickness of 5.88 ± 0.83 mm,endometrial change range of-1 ~ 2mm,including 2 cases of intima thickness decreased by 1mm,7 cases of intimal thickness Changes,7 cases ?of patients with intimal thickness 7mm;an average increase of 0.77 ± 0.73 mm,bionic electrical stimulation group compared with preoperative and endometrial thickness,the control group before and after surgery compared with endometrial thickness,Comparing the endometrium thickness of the bionic electrical stimulation group with the control group,the difference of the endometrium thickness before and after treatment between the bionic electrical stimulation group and the control group was statistically significant,P<0.05.(3)Recovery of menstruation after 3 months: The menstrual condition of all patients after treatment was increased compared with before treatment.The recovery rate of menstruation was 51.4%,the improvement rate was 40%,and the ineffective rate was 8.6% in the biomimetic electrostimulation group.Recovery efficiency was 31.4%,improvement rate was 60%,and ineffective rate was 8.6%.Biomimetic electrostimulation group had significantly more menstrual recovery than the control group,but there was no significant difference between the two groups,P>0.05.Conclusions: Adjuvant treatment of Biomimetic electrical stimulation after TCRA can promote the repair of endometrium,and has certain curative effect on preventing the recurrence of intrauterine adhesions.It is worthy of clinical recommendation that the Biomimetic electrical stimulation should be recommended in the TCRA postoperative adjuvant therapy program. |
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