Clinical Study Of Ssr Combined With IL-17A In Diagnosis And Treatment Of Post-stroke Depression

Objective:To study the clinical significance of skin sympathetic response(SSR)combined with plasma interleukin-17A(IL-17A)in the diagnosis and treatment of post-stroke depression(PSD).Methods:1.80 stroke patients were divided into simple stroke group(S group)and post-stroke depression group(PSD group)by HAMD,and 37 healthy people were also included as control group(N group),then used the NIHSS assassed the stroke severity.The SSR tests were performed on each of the three groups using a Keypoint electromyography manufactured by Medtronic Inc.in the United States,then observed the differences between the three groups.2.Patients in the post-stroke depression group were treated with conventional cerebral infarction drugs and escitalopram oxalate,HAMD and NIHSS scores were measured before and after 2 weeks of treatment At the same time,SSR and the content of plasma IL-17A were measured.Before and after treatment whether the various indicators have differences are analyzed,and the correlation between HAMD score,SSR test results and plasma IL-17A before and after treatment of the post-stroke depression patients was further discussedResults:1.Compared with the normal control group(N group),the latency of SSR in the upper and lower limbs both prolonged and the amplitude was reduced in the S group and the PSD group(P<0.01,P<0.001).Compared with S group,the latency of SSR in upper and lower limbs was longer in PSD group,the difference was statistically significant(P<0.05),but the difference in amplitude was not significant(P>0.05).In the post-stroke depression group,the latency of SSR was positively correlated with the HAMD score,and the amplitude was negatively correlated with the HAMD score.In the simple stroke group,the latency of the SSR of lower limb was positively correlated with the score of HAMD.In the normal control group,there was no correlation between the various SSR results and the HAMD score.2.In the PSD group,the latency of SSR in upper and lower limbs was positively correlated with HAMD score,and the amplitude was negatively correlated with HAMD score.In the S group,the latency of SSR in lower limbs was positively correlated with HAMD score.There was no correlation between SSR results of N group and HAMD score.3.The NIHSS score in the PSD group was higher than that in S group,the difference was statistically significant(P<0.01).There was no correlation between NIHSS and SSR,HAMD in the PSD group and the S group.4.In the PSD group,the scores of HAMD and NIHSS after treatment were lower than before treatment,and the difference was statistically significant(all P<0.01),and the latency of SSR in upper and lower limbs was shorter and the amplitude was higher than that before treatment,the difference was statistically significant(all P<0.05).After treatment the content of IL-17A in the PSD group was lower than before treatment,and the difference was statistically significant(P<0.05).5.In the PSD group,the content of IL-17A before treatment was positively correlated with the latency of SSR in upper and lower limbs,but had no correlation with the amplitude,and the content of IL-17A after treatment was positively correlated with the latency of SSR in the upper limb.The content of IL-17A before and after treatment in PSD group was positively correlated with HAMD score and NIHSS score.Conclusion:1.PSD patients can determine the degree of depression and illness severity after stroke through HAMD,NIHSS and detection of abnormal changes in the latency of SSR-2.After PSD patients were treated with antidepressant drugs,the latency of SSR was shortened,the amplitude was increased,the content of IL-17A was decreased,and the degree of depression and the condition were all improved3.Through HAMD,NIHSS,and combining the detection of SSR and IL-17A to provide a scientific basis for accurate diagnosis and efficacy evaluation of post-stroke depression.