Fluid-attenuated Inversion Recovery Vascular Hyperintensity And Long-term Functional Outcome In Patients With Acute Ischemic Stroke

Background and Purpose:Fluid-attenuated inversion recovery vascular hyperintensity(FVH)has been used to assess leptomeningeal collateral circulation in acute ischemic stroke patients;nonetheless,but clinical outcomes of patients with FVH can be very inconsistent.The aim of the present study used two different ways to assess FVH and explored its relationship with long-term functional outcome in patients with acute ischemic stroke,on account of atherosclerotic steno-occlusive lesions in the M1 segment(?70%).Methods:144 AIS Patients with atherosclerotic steno-occlusive lesions in the M1 segment were consecutively selected from a prospectively collected ischemic stroke database from the First Affiliated Hospital of Zhengzhou University and All consenting patients were included from January 2010 to June 2015.The ways of Stephane Olindo and Alberta Stroke Program Early CT Score(ASPECTS)were used to evalute FVH.We defined one-year mRS score? 2 as good long-term functional outcome,while one-year mRS score > 2 as poor long-term functional outcome.Compare clinical and radiological datas differences between the two groups.Results:Among the one hundred and forty-four patients,FVH was observed in 126(87.5%)patients.FVH,according to Stephane Olindo,was not associated with the 1-year functional outcome.However,a lower rate of FVH outside the diffusion weighted imaging(DWI)positive area Alberta Stroke Program Early CT Score(ASPECTS)(FVH-O-ASPECTS)and in contrast a higher rate of FVH inside the DWI positive area ASPECTS(FVH-I-ASPECTS)were predictors of poor outcome in univariate analysis(p < 0.001,p = 0.001,singly).This association kept pregnant in the binary logistic regression(OR(odds ratio),0.33;95% CI,0.22-0.51;p<0.001;and OR,2.05;95% CI,1.28-3.29;p=0.003,severally).Conclusions:The distribution,not the extent of FVH was associated with long-term functional outcome in patients with AIS.That is,the more FVH-O-ASPECTS,the relatively better long-term functional outcome;in contrast,the more FVH-I-ASPECTS,the correspondingly poorer long-term functional outcome.