Clinical Observation Of An Chang Decoction In The Treatment Of Diarrhea Type Irritable Bowel Syndrome Of Liver Stagnation And Spleen Deficiency Syndrome

Object: To observe the clinical effect of an Chang Decoction on diarrhea type(liver depression of spleen deficiency)irritable bowel syndrome.To evaluate the clinical curative effect of an intestinal soup on diarrhea type irritable bowel syndrome by changing the clinical efficacy of Chinese medicine,symptom improvement,the content of blood CGRP and VIP,psychological state,recurrence rate and safety,so as to provide clinical basis for further study of an intestinal soup in the future,and to use an intestinal soup to benefit the general I in the future.IBS-D patients have a positive social significance.Methods: 60 patients who met the inclusion criteria were randomly divided into treatment group and control group,30 cases in each group.The treatment group was given oral administration of an chang decoction and 1 doses daily.It was taken after breakfast and evening meal.The control group was given Trimebutine Maleate Capsules,1 capsules / time,3 times a day.Two groups of patients were used for 8 weeks.The symptoms score of two groups of patients,the IBS-SSS scale,the content of CGRP and VIP,the psychological state(SAS,the SDS scale integral),and the adverse reactions during the treatment were recorded before and after the treatment.The patients were followed up for 8 weeks after treatment,and the recurrence was observed.Results:(1)The clinical efficacy of Chinese medicine: the total effective rate of the treatment group was 93%,and the total effective rate of thecontrol group was 66.7%.The total effective rate of the treatment group was higher than that of the control group(P<0.05).(2)Symptoms of traditional Chinese medicine: symptoms of single Chinese medicine,after treatment,the symptoms of the treatment group were significantly improved(P<0.05),and the control group had different degrees of improvement(P<0.05)in abdominal pain,diarrhea and abdominal distention(P<0.05);after the treatment,the total score of the two groups was lower than that of the former(P<0.05).The treatment group was significantly better than the control group(P<0.01).(3)IBS-SSS scale integral aspects: after treatment,the scores of IBS-SSS in the two groups were lower than those in the front(P<0.01),and the treatment group was better than the control group after treatment(P< 0.01).(4)Blood of CGRP,VIP: after treatment,the content of CGRP and VIP in the two groups was lower than that of the former(P<0.05),but there was no significant difference between the treatment group and the control group(P>0.05).(5)Psychological state: in the two aspects of SAS score and SDS score,the scores of the two groups were significantly lower than those before the treatment(P<0.01),and the curative effect of the treatment group was significantly better than that of the control group,the difference was statistically significant(P<0.01).(6)Safety: no adverse reactions occurred in the two groups before and after treatment.(7)Recurrence rate: the recurrence rate in the treatment group was 10.7%,and the recurrence rate in the control group was 45%.The treatment group was better than the control group(P<0.05).Conclusion : Ann bowel decoction in the treatment of patients with IBS-D its clinical curative effect both in terms of overall curative effect,and in the improvement of TCM symptoms were significantly better thanthat of maleic acid trimebutine capsule,and also from theSAS scale and SDS scale can be seen that the advantage of intestinal soup.Therefore,enteric decoction is useful for the treatment of diarrheal disease(liver and spleen deficiency).