Expression Of Of TNFR And IL-6 R In Myofascial Trigger Points

Background and objective:Myofascial pain syndrome(MPS)is a chronic pain disease,characterized by physical examination can hit on affected skeletal muscles of rope sample or induration(nodule),in order to exist within the muscle and fascia of Myofascial trigger points(MTrPs),with features of acupuncture MTrPs or pressure can lead to local pain?Stuies have observed IL-1??IL-6?IL-8?TNF-? level within the MTrPs increaed?The increase of these biomarkers may be related to local skeletal muscle injury and ischemic reaction caused by muscle tension compression.But previous research didn't clarify the change of TNF-?,IL-6 in the muscle cells in patients with MPS,so this research aims to detect the receptor of TNF-? and IL-6 expression levels in different pathological types of muscle tissue.Methods:20 patients to receive spinal surgery with MTrPs(diagnose by clinical diagnostic standard Put forward by simons[1])in erector spinae muscles or receive hip replacement surgery with MTrPs in gluteus medius were assigned into group M(n=20).while 15 volunteers to receive cervical vertebral surgery or hip replacement surgery without MTrP were assigned into group C(n=15).Use immunohistochemisty staining to detect the expression of TNFR?IL-6R.Results:TNFR2:In region B(in the adjacent region where sarcomeres abnormally contracted)of group M,the expression was relatively increased(p<0.01 vs.group C).IL-6R:In region B of group M,the expression was relatively increased(p<0.05vs.group C).Conclusion:The levels of IL-6R and TNFR2 were increased in the muscle of MTrPs.Skeletal muscles release pro-inflammatory mediators as a secretory tissue,participates in the regulation of abnormal sarcomere contraction of MTrPs and chronic pain,but it's specific pathophysiological mechanism remains to be further studied.