Clinical Study Of Salvianolic Acids On Resting-state FMRI In The Treatment Of Acute Cerebral Infarction

Objective:To observing the curative effect of Salvia miltiorrhiza polyphenols in improving neurological deficit in patients with acute cerebal infarction.And to analyzing the possible mechanisms by using resting state functional magnetic resonance imaging.Methods:According to the Chinese Journal of Cerebral Angiopathology,revised by the Chinese Medical Association Neurology Branch,"China Acute Ischemic Stroke Diagnosis and Treatment Guidelines 2014" patients with acute cerebral infarction at the anterior circulation system with neurological dysfunction was selected,followed randomized,controlled clinical trials principles.Patients were divided into control group: conventional drug treatment;Salvia miltiorrhiza polyphenols treatment group: On the basis of conventional drug therapy,Salvia miltiorrhiza polyphenolic acid was injected.The NIH Stroke Scale(NIHSS)score was used to assess the degree of neurological dysfunction before and after the treatment in both groups;and patients with acute hemispheric acute cerebral infarction were selected again those patients(all were right-handed),divided into the control group and Salvia polyphenolic acid treatment group,given them treatment after resting state functional magnetic resonance examination,observing the characteristics of resting state functional magnetic resonance imaging after the treatment.Results:In this study,70 patients with acute cerebral infarction at the acute stage of the anterior circulation system with neurological dysfunction were selected.35 patients in the control group were enrolled,and 32 patients were finally completed.35 patients in the Salviae polyphenolic acid treatment group and 34 patients were finally completed.The NHISS scores of the two groups before treatment and 10 days after treatment were compared,and the NHISS scores before and after treatment in the control group were compared.After treatment,the scores were lower than before treatment.According to the statistics before and after treatment,P<0.001 was statistically different.The NHISS scores before and after treatment in the salvianolate-treated group were significantly different.After treatment,the NHISS score was significantly lower than before treatment.According to statistical analysis,there was a statistical difference between the treatment group and the pre-treatment group.Comparison between Salvia polyphenolic acid treatment group and control group: comparison before treatment(P=0.348),post-treatment comparison(P=0.862),all P>0.05,there is no statistical difference.The difference before and after the treatment was P=0.008(P<0.05),statistically significant.In the selected 70 patients,the patients with acute hemisphere acute cerebral infarction(all right-handed)were selected again and divided into control group: 11 patients were finally completed;and Salvia polyphenolic acid treatment group: 6 patients were finally completed.Resting state functional magnetic resonance imaging was performed 10 days after treatment in both groups.The global values of ALFF,ReHo,and ReHo were compared between the two groups(the above indexes respectively reflect the activation of neurons and local consistency),and the treatment group was found on the contralateral side.The values of some brain functional areas in the hemisphere were higher than those in the control group,indicating that the neuronal local consistency and neuronal activation of the healthy hemisphere in the treatment group were significantly greater than those in the control group.Conclusion:(1)Salvianolic acids for injection significantly improved neurological dysfunction in patients with acute cerebral infarction.(2)Salvianolic acids for injection can activate the neurons in the healthy hemispheres of patients with acute cerebral infarction,thereby strengthening the compensatory function of the ipsilateral hemispheric function and better improving the neurological dysfunction in patients with acute cerebral infarction.