The Use Of Intravenous Lidocaine In Carotid Endarterectomy

Objective:The preliminary report is designed to explore the use of intravenous lidocaine in CEA,examine its neuroprotective effect,evaluate its influence on intraoperative hemodynamics,postoperative recovery and cognitive function.Methods:19 patients were divided into Lidocaine group(n=9)with routine general anesthesia + lidocaine(1.5mg/kg bolus + 2mg/kg/h infusion till end of CEA)or Control group only with routine general anesthesia.Radial arterious serum were collected at the point of pre-anesthesia and 2h after the aortic cross-clamp release.The value of postoperative S100? minus the preoperative(?S100?,ng/L)between 2 groups were compared.Intraoperative hemodynamics,postoperative recovery and cognitive function were recorded.Results:?S100? is lower in lidocaine group(20.78±9.28 vs 41.60±34.26,P=0.093).In subgroup patients with motor dysfunction,?S100? is significantly lower in lidocaine group(22.3±10.5 vs 63.3±34.2,P=0.025).Intraoperative hemodynamics is more stable in lidocaine group.Patients in lidocaine group have more satisfying postoperative recovery.1 patient in Control group occurs CHS.Conclusion:In this study,lidocaine shows neuroprotective effect for CEA patients,particularly for patients with motor dysfunction which indicates high perioperative risk.Lidocaine can weaken intraoperative harmful stimulus and promote postoperative recovery.Its adverse effects are also uncommon.However,those need to be tested under lager sample.