A Clinical Risk Factors Analysis For Interstitial Lung Disease In Patients With Anti-Jo-1 Antibody Syndrome

Objective:Anti-Jo-1 antibody syndrome is a special subtype of idiopathic inflammatory myopathy.Interstitial lung disease(ILD)is a common and severe complication of anti-Jo-1antibody syndrome and associated with poor prognosis.The incidence of interstitial lung disease(ILD)in anti-Jo-1 syndrome is about 67~100%,which is the main cause lead to death of the anti-Jo-1 syndrome.The aim of our study was to identify risk factors for ILD by evaluating both clinical and biochemical features in anti-Jo-1 antibody syndrome patients with or without ILD.Methods:From January 2010 to January 2018,medical records of 58 Anti-Jo-1 antibody syndrome in Chinese Han patients in the first affiliated hospital of zhengzhou university.we identified subjects with demographics,high-resolution computed tomography(HRCT),clinical manifestations and laboratory tests.ILD was diagnosed by the radiologist and clinical doctors combination HRCT.Results:The patients were divided into ILD group(43 patients)and non-ILD group(15 patients).The results were statistically significant in fever(58.14 vs 26.67%),arthritis(74.42% vs 26.67%),Raynaud's phenomenon(55.81% vs 13.33%),anti-SSA/Ro52 antibody(81.40% vs 26.67%),ESR(58.14% vs 26.67%)and CRP(51.16% vs 20.00%)(P<0.05).The results showed the difference wasn,t statistically significant in muscle weakness proximal,myodynia,mechanic,s hand,Gottron papule,pulmonary arterial hypertension,ANA,anti-SSA/Ro60 antibody,RF,CCP,CK,LDH,ALT,AST(P>0.05).Multivariable logistic regression analysis that showed risk factors that may have increased the risk of developing ILD in anti-Jo-1 antibody syndrome patients included arthritis(OR 10.224,95%CI 1.605-65.135),Raynaud's phenomenon(OR 14.240,95%CI 1.430-141.860),anti-SSA/Ro52 antibody(OR 9.854,95%CI 1.407-69.017).Conclusions:The incidence of interstitial lung disease among patients with anti-Jo-1 antibody syndrome is high,arthritis,Raynaud's phenomenon and anti-SSA/Ro52 antibody increased risk for developing ILD in anti-Jo-1antibody syndrome.