Relationship Between Vitamin D Deficiency And Elderly Obese Hypertensive Patients

Objective: At present,there are more and more researches on the effects of vitamin D deficiency on hypertension in China and abroad.This article studies the changes of serum vitamin D levels in elderly obese hypertensive patients.Clinically,vitamin D is often supplemented for the treatment of senile hypertension,especially for Elderly obese and overweight patients can not only be treated with vitamin D,but should also take advantage of the sun and often participate in outdoor activities.The purpose of this study is to investigate whether the relationship between vitamin D deficiency and obesity in elderly hypertensive patients is indeed related to blood pressure,and to provide further theoretical basis for the future increase in the use of vitamin D in the treatment of elderly hypertension and clinical cardiovascular disease prevention and treatment.Methods: Collect geriatric patients(age >60 years old)from July 2016 to February 2018 at the Department of Geriatrics,Yiji hospital,and record the data included in the study according to the blood pressure and body mass index.In the history of the disease,patients were divided into 52 patients with hypertension but normal body mass index,39 patients with normal blood pressure but with obese body mass index,47 patients with hypertension and body mass index obese group,and 41 healthy controls.A detailed history of the subject was collected,the patient's disease history,past history,current medical history,and diet and lifestyle were measured.The patient's weight and height were measured to further calculate the body mass index(BMI)= weight(kg)/height 2(m2).The blood pressures of the patients included in the study were measured and measured continuously for 3 times while the patient was in a state of rest.Mean blood pressure was recorded.Early morning venous blood was collected from the patient's fasting condition.Samples were analyzed using the Automatic Biochemical Analyzer in the hospital's laboratory and analyzed for liver and kidney function,lowdensity lipoprotein cholesterol,and serum calcium levels.The serum 25(OH)D level was measured by Radioimmunoassay using the Nuclear Medicine Shanghai Sn-69513 immunoassay counter of our hospital and Dia Sorin's detection kit of Italy.The patient's heart ejection fraction was measured and all department doctors strictly followed the procedure.The differences between the above-mentioned multiple indicators were compared between the groups.According to serum vitamin D levels were divided into vitamin D deficiency group,insufficient group and vitamin D sufficient group.Observe the differences in blood pressure,body mass index and other relevant biochemical indicators measured between different vitamin D levels.The correlation between serum 25(OH)D levels and the incidence of hypertension in elderly obese patients was analyzed.Results: The patients with hypertension and body mass index obese group had lower levels of serum 25(OH)D and Blood calcium and higher levels of low-density lipoprotein compared with healthy controls.The difference was statistically significant(P<0.05);Blood pressure but body mass index obese subjects had lower serum 25(OH)D levels,increased systolic blood pressure,and low-density lipoprotein levels compared with healthy controls,with statistically significant differences(P<0.05).Hypertension but normal body mass index Compared with the healthy control group,Blood calcium decreased,serum 25(OH)D levels decreased,the difference was statistically significant(P <0.05).Between the experimental groups,the levels of 25-OH-Vit D3 were higher in patients with hypertension and body mass index obesity than in those with hypertension but normal body mass index(P<0.05).Normal blood pressure but body mass index obese patients had lower levels of 25-OH-Vit D3 than those with hypertension but normal body mass index,and the difference was statistically significant(P<0.05).The level of 25-OH-Vit D3 was lower in hypertensive patients with normal body mass index but normal blood pressure but obese with body mass index,and the difference was statistically significant(P<0.05).Serum vitamin D levels were negatively correlated with systolic blood pressure,low-density lipoprotein cholesterol and BMI,and positively correlated with serum calcium.Conclusion: 1.Serum vitamin D levels in elderly hypertensive patients are lower than those in healthy controls.Serum vitamin D levels are significantly reduced in older hypertensive and obese patients.2.Vitamin D deficiency in elderly patients can easily lead to increased cardiovascular risk factors such as high blood pressure,weight gain,and elevated LDL cholesterol.3.Serum vitamin D levels were independently and negatively correlated with the patient's blood pressure and LDL cholesterol and BMI,and positively correlated with serum calcium.Proper vitamin D supplementation may be a simple and effective means of preventing and treating primary obesity in elderly patients with obesity.