Incidence Of Poststroke Epilepsy:A Meta-analysis

Objectives:By using the method of meta analysis,collect cases about the incidence of epilepsy after stroke,researchers report in a meta-analysis and,it is concluded that the incidence of epilepsy after stroke and its characteristics,in order to guide clinical treatment.Methods:Collection published in 1990.01-2017.12 years PubMed,embase,the Cochrane library,web of science,Google,ten thousand medical network and China hownet,VIP,abstract database of Chinese biomedical literature in both Chinese and English,the subject"cerebral infarction,stroke,epilepsy,seizures,incidence of a disease"to carry on the literature search,make literature into and exclusion criteria,and then according to this standard evaluator by two respectively from the retrieval of literature literature screening to meet the requirements,if the split,needs further discussion or arbitration by a third party.Then the quality of the literature was evaluated according to the non-randomized controlled trial evaluation table.From the literature into the standard and quality requirement of literature to extract data information,including:the first author's last name,publication date,country,type of study design,diagnostic criteria of stroke and epilepsy seizures,sample size,number,gender,the average age of patients.Finally,data analysis was carried out through stata14.0,and heterogeneity passed I~2 test(50%of I~2>indicates obvious heterogeneity).I~2<25%indicates that the heterogeneity is not obvious).50%of I~2>adopts random effect model to process data,and vice versa.If there is heterogeneity,subgroup and sensitivity analysis are carried out for effect quantity.Results:In the end,the English literature from 1~2 research groups was included in 520 articles.Through data processing by stata,the incidence rate of early-onset epilepsy was 4.6%(95%CI:0.034-0.058),the incidence of late-onset epilepsy is 6.8%(95%CI:0.051-0.084);1 week or 2 weeks of early-onset epilepsy with no difference between the total incidence,morbidity and more than 2 weeks delay incidence of epilepsy is higher than the overall incidence,hints of the definition of time difference of epilepsy after stroke mainly affect the incidence of late-onset epilepsy.Average age greater than 60,5.0%incidence of early-onset epilepsy(95%CI:0.035-0.065)of late-onset epilepsy incidence of 7%(95%CI:0.051-0.089),8 average age greater than 65,5.2%incidence of early-onset epilepsy(95%CI:0.033-0.072),the incidence of late-onset epilepsy 7.6%(95%CI:0.053-0.099).Conclusion:Retrieve this study published in 1990-1990 of epilepsy after stroke related research literature,the meta-analysis concluded that 4.6 for every100 people in the stroke patients may appear early-onset seizures,6.8 for every 100 people could be late-onset epilepsy,and is a high incidence of epilepsy after stroke in the elderly population,the older you get,the higher the incidence of a disease.