The Search Of The Serum Vitamin D Horizontal And Meaning Ofactivity Level Tuberculosis Person

ObjectiveEvaluate activity level tuberculosis person the horizontal of the serum calcium phosphor etc.element,and evaluate the horizontal and relationship with pathological changes serious degree of the activity level tubercle patient the serum vitamin D further;The initial inquires into the reciprocity of vitamin D and tuberculosis.outbreak of low level and is second cluster of with T cell of reciprocity;Combine initial disclosure the vitamin D effect the machining of human body immunity function,for aftertime apply vitamin D unite anti-tubercle medicine treatment tuberculosis of the feasibility provide science basis.Contents and methodAccording to going into a standard selection sea river hospital in Tianjin City of set hospitalized for 2011-2013 years of beginning cure activity level tuberculosis sufferer's 60 Be test set and same period normal become adult check-up 30 are a matched control.Carry on the serum calcium phosphor vs 60 experiment sets and 30 matched control specimens concentration,25-the Qian radicle vitamin D concentration and T cell Be second cluster of to measurese respectively,get result behind two sets of carry on collate,and carry on statistics analysis.The post-is divided into 60 tuberculosis sufferers 3 sets according to the pathological changes serious degree,vs 3 sets of vitamins variance analysis inside the D horizontal progress set,and inside the set 22 compare.The end will test a set 60 vitamin D result and CD 4+ T cell result progress reciprocity analysis,get conclusion.Combine to combine collection vs result carry on analysis and discussion.Result1.Activity level tuberculosis set patient serum calcium the concentration have with normal matched control contrast to show the discrepancy of Zhao statistics(P=0.000),the experiment set is more obviously low than a matched control;The serum concentration has no obvious statistics discrepancy with matched control;(P=0.549)But serum phosphor the contents is as well lower than a matched control,also obvious statistics discrepancy.(P=0.018)2.The result displays an experiment set serum 25-the Qian radicle vitamin D concentration is 21.740 ± 4.546 nmol/l,matched control serum 25-the Qian radicle vitamin D concentration is 25.236 ± 4.435 nmol/1,P<0.05,there is statistics meaning,can think activity level tuberculosis person serum amid 25-the Qian radicle vitamin D horizontal is more obviously low than a normal matched control;3.Is divided into 60 patients 3 sets pass variance analysis the display set the memory according to the pathological changes serious degree at discrepancy,approval set come 22 compare and display advanced case tuberculosis a person team the vitamin D horizontal inside the body is more obviously low than a light and mid-degree set.4.Passing is second cluster of to T cell of measuring prompt activity level tuberculosis person CD 4+ T cells is more obviously low than a normal matched control,have statistics meaning in the middle of the serum;Two sets of the CD8 T cell and CD4/CD8 ratio controlses have no obvious discrepancy.But the vitamin D horizontal and CD 4+ T cells have apparent reciprocity.Conclusion1.This on trial result suggests that activity level tuberculosis person blood calcium the horizontal is more obviously low than a healthy adult,its reason is various,among them it endocrine conditioning the factor is a most of,because of the human body calcium phosphor metabolism relate to with vitamin D closely,past we and then carried on a further search to the concentration of vitamin D.2.The experiment verified activity tuberculosis patient the horizontal of vitamin D is more obviously low than a normal adult in the middle of the serum,the scarcity of the vitamin D horizontal will raise the easy emotion of tuberculosis.However,the horizontal relationship with tuberculosis serious degree of vitamin D without definitely report.This experiment approval tuberculosis different and serious degree of vitamin D horizontal analysis get conclusion,the advanced case tuberculosis vitamin D horizontal inside the human body is more obviously low than a light and mid-degree set,past the vitamin D horizontal not only with tuberculosis of occurrence existence correlation,and with tuberculosis of serious degree existence correlation.3.The action machining of vitamin D exists a little bit in many ways,its immunity regulates of the action is nucleus and foundation.The vitamin D can produce result to various cells and the cell factors and effect the immunity function of the air frame but the occurrence and serious degree of the impact tuberculosis thus.The tuberculosis immunity is the cell immunity that the T cell lies to lead,the T lymphoid cell has action in the centre in the tuberculosis immunity.Have already proven CD,4+ T cells are the nucleuses of the anti-tubercle safeguard immunity,lie to lead safeguard immunity.This experiment equally proved the more normal person of 4+ T cells of the activity level tuberculosis person's CDs is obviously lowly,and the vitamin D horizontal and CD 4+ T cell horizontals exist apparent reciprocity in the middle of the person in the activity level tuberculosis,Hint vitamin D in effecting human body immunity function and CD 4+ T cells relate to closely and have already had now the cultural heritage reports CD,4+ T cells secrete of some cell factors and vitamin D exist a lot of correlations,mutual impact.4.This experimental investigations has already well explained vitamin D for tuberculosis of meaning,and provide the theoretical basis of next move treatment.The abroad has already had the treatment effect that the sufferer whom the cultural heritage verification lacks for vitamin D add vitamin D to reduce several rates of being infected the tubercle and can strengthen tuberculosis now.However,the cultural heritage reports big fraction all fm abroad,our country the search in this aspect still few,especially big sample quantitative search and clinical trial scarcity.And,because of the human race discrepancy,Chinese application after the vitamin D whether will also generate impact to still need after preparing vs the tuberculosis further a great deal of search in the future verify.There is aggressive action after curing apply to repair calcium and vitamin D with the routine a treatment at the same time in the tuberculosis process should is able to the pais the restoring of patient and prepare in the normal.Difficult today find out such as passing a search to strengthen to cure an effective method day by day in the treatment of tuberculosis,undoubtedly will bring sufferer tremendous advantage.The writer will also make a further search to this.