A Method For Preparing Bio-active Glass Artificial Bone By 3D Printing

The use of artificial bone scaffolds to repair bone damage has always been a hot spot.The artificial bone scaffold is used as a carrier for cell and the pore for providing nutrient for cells.It is required to be consistent with the external shape of the replaced bone,and it should have the same internal structure,the marrow cavity,loose and certain mechanical properties as the bone.The conventional preparation method and the commonly used extrusion 3D printing are difficult to meet the structural size and the controllable pore structure.But the Digital light processing can adjust the illumination parameters to achieve the expected structure.As a biologically active bone substitute material with a refractive index similar to that of a photosensitive resin,45S5 bioactive glass has been widely used in the manufacture of bone tissue engineering scaffolds,but it needs to be sintered after molding.As long as the printing process,sintering process and influencing factors are mastered,the artificial bone support with controllable structure and controllable size can be printed.Besides,as a molding process plan,more molding technical support is provided for the development of bone tissue engineering field.Therefore,research on artificial bone DLP molding is of great significance in the field of bone tissue engineering.Based on the analysis of the forming effect,this paper conducts a comprehensive and systematic study on the process of artificial bone scaffold DLP printing.The main contents of this paper include:Printing slurry: According to the requirements of DLP printing,to select and analyze the materials.Through mixing,the printing solids with different solid content can be used to form a film with a maximum solid content of 70%.Determination of printing parameters: The standard model of printing was performed using a70 % solids slurry,and the printing parameters were analyzed by the dimensional deviation of the molding,including the influence of the exposure amount and the delamination parameters on the molding,and the printing parameters conforming to the 70 % solid content slurry were obtained.The stent digital model was further designed,and a 70 % solids sample was printed using this printing parameter for the next experiment.Sintering experiment: set different sintering parameters,carry out multiple sets of contrast experiments,compare the dimensional weight change,surface morphology and mechanical strength of the sintered stent,analyze the influence of sintering process parameters on the stent forming,and obtain a perfect set.Sintering process route.Contrast experiments with different solid contents: according to the process rules obtained inthe previous chapters,the stents with different solid contents were printed according to different solid content processes,and the structure,morphology and mechanical strength of the stents were analyzed.