Research And Development Of Wireless Extensible Physiological Parameters Monitoring Patch System

Physiological parameters are the most basic and most important life indicators of the human body.In healthy conditions,physiological parameters are maintained within a normal range,and many diseases can be predicted by monitoring changes in these parameters.In daily life,when people do physical labor or high-volume training,if the body is overworked because of the inability to understand the state of fatigue in time,it will not only reduce the work or training efficiency in a short period of time,but also reduce the body performance after long-term fatigue,which will lead to sub-health.In addition,we will inevitably suffer from a variety of wounds(such as scratches,burns,burns,surgical wounds,etc.)in our lifetime,and wound healing has always been a major clinical problem.The current clinical nursing method is to dress the wound by dressing and to check the healing state of the wound by changing the dressing.This "black box" state and delay in information acquisition are likely to delay the optimal timing of wound treatment,however,we can obtain wound healing information in time by monitoring some of the physiological parameters of the wound(such as temperature,pH,Blood oxygen concentration,etc.).Therefore,real-time wireless monitoring of physiological parameters has broad application prospects in disease monitoring,exercise and fitness training,and medical monitoring.In this paper,a novel wireless stretchable photoelectric sensor patch system is developed.The patch is based on photoplethysmography(PPG)and organically modified silicate(ORMOSIL)film,which can realize real-time monitoring various physiological information,such as Pulse Oxygen Saturation(SpO2),heart rate(HR)and sweat PH;and when used for wound information monitoring,wound physiological parameters such as SpO2 and PH can be obtained in real time.In addition,we also develope a wireless stretchable smart dressing patch system in this paper,which can monitor the wound temperature in real time and supplement the release of drug in the dressing layer to promote wound healing.At the same time,this paper uses a variety of in vivo and in vitro test methods to verify that the two systems can stably and reliably monitor the corresponding physiological parameters under different scenarios.The main work,innovations and achievements of the thesis are as follows:1.Research and development of wireless stretchable photoelectric sensor patch system.The system is fabricated on a flexible circuit board(FPC)and coated with polydimethylsiloxane(PDMS).The overall design is in the shape of a bandage and uses a serpentine connection to achieve 35%ductility and can fit snugly to the skin or the wounds to improve measurement accuracy.In addition,the sensing part is composed of a commercial blood oxygen sensor SFH7050 coated with a layer of PH sensitive film,wherein the PH sensitive film is prepared by spin coating method,and finally realizes the function of monitoring multiple physiological parameters by using one sensing chip,which is more consistent with the future development trend of the wearable field.2.Research and development of wireless stretchable smart dressing patch system.The circuit process and overall structure are consistent with the wireless extendable optoelectronic sensor patch system.After the system is placed on the wound surface,the wound surface temperature is monitored in real time through the mobile phone APP.When the temperature is too high,in order to prevent inflammation of the wound surface and then evolve into a chronic wound,we can open the UV light of system by the APP to illuminate the dressing layer.Then the relevant antibacterial drugs are released to achieve automatic wound treatment.3.Feasibility verification of two systems.Through a series of in vitro and in vivo experiments,it is verified that the wireless stretchable photoelectric sensor patch system can accurately measure SpO2,HR and sweat PH with the range of 0%～100%,25～250 bpm and 4.0～8.0,whose sensitivity are ±2%,±1 bpm and 4.42 mV/PH,respectively.And through the Bana pig wound test,it was verified that the system can also be applied to wound monitoring.At the same time,through the in vitro and Bana pig wound experiments,it was verified that the wireless stretchable smart dressing patch can accurately measures temperature and controls drug release in the dressing layer to achieve bacteriostatic effect,and with a measurement accuracy of ±0.3 ℃ over a temperature range of 25 to 42℃.