The Biocompatible AuPd@PVP Core-shell Nanoparticles For Synergetic Therapy Of Enhancement Of Radiosensitivity And Photothermal Cancer Therapy

Nanomaterials have been studied and being applied to more and more fields for their outstanding properties.On account of the similar dimensions to the biomolecules,smart designed nanostructures are the rising materials in biotechnology and medical engineering.Smart designed nanostructured materials have attracted much attention due to their similar scales to biomolecules and their multipurpose applications in diagnosis and treatment.A method for synthesis of AuPd@PVP nanoparticles using ascorbic acid(AA)as a reducing agent in the presence of the surface stabilizer polyvinyl pyrrolidone(PVP)was proposed.The presence of PVP shell promises good biocompatibility and makes it easy on the surface modification.The combination takes the advantage of both Au and Pd that the electronic coupling between the two metal elements strengthens the photothermal conversion ability and expands the absorption region.The properties make AuPd@PVP nanoparticles superior photothermal conversion agent applied to photothermal treatment(PTT)under low power near infrared laser irradiation.AuPd@PVP nanoparticles can also be used as sensitizer in radiotherapy(RT).Combined application of PTT and RT improves the efficiency of tumor treatment.Therefore,the excellent properties of AuPd@PVP nanoparticles in photothermal conversion,radiosensitivity,biocompatibility and other aspects indicate its enormous potential in tumor treatment.