Studies On Copper-catalyzed Non-directed Hydrosilylation Of Cyclopropenes

Organic silicon compounds are widely used in the production of materials science and medicinal chemistry,and are closely related to the development of human society.As an important class of intermediates in synthetic chemistry,organosilanes can be further converted into high-value silicon-based materials and many other functional compounds.On the other hand,the structural unit of cyclopropane is also an important synthetic building block.It is widely present in bioactive natural molecules and drug molecules,and can be used in modern organic synthesis through various useful chemical conversions.Currently,researchers have reported several methods for the synthesis of cyclopropylsilane,but these methods require metal reagents,precious metal catalysts or expensive silicon reagents.Therefore,exploring a method for the synthesis of cyclopropyl silicon compounds from the cheap and readily available raw materials has attracted our interest.Obviously,direct hydrosilylation of cyclopropene is a simple and efficient strategy to provid cyclopropyl silicon compounds.In this thesis,we successfully develped the hydrosilylation of cyslopropenes with the inexpensive and low-toxic copper salt as the catalyst through an insertion of in-situ generated CuH species into cyclopropenes.The method characters good step economy and good functional group compatibility,and has high diastereoselectivity.Moreover,3,3-disubstituted and 1,2-disubstituted cyclopropenes can also react react smoothly.Consequently,this method provides a simple and direct approach for the synthesis of valuable multi-substituted and challenging fully substituted cyclopropylsilanes with high diastereoselectivity.