Preparation And Properties Of High-strength Antibacterial Dressing Hydrogel

Hydrogels are macromolecular hydrophilic networks formed by water-soluble polymers through chemical or physical crosslinking.Due to the special properties of hydrogels,such as high sensitivity to physiological environment,hydrophilicity,high water content and sufficient flexibility,these properties make hydrogels very suitable for use as wound dressings.However,most wound dressing hydrogels have poor mechanical properties and cannot meet the protection of wounds under external mechanical force.The synthesis process is complicated and expensive.The main idea of this work is to prepare a composite hydrogel that can meet the mechanical properties of the wound dressing hydrogel by a simple in-situ synthesis method.The specific research content is as follows:(1)Using polyvinyl alcohol(PVA)and polyvinylpyrrolidone iodine complex(PVP-I)as raw materials,without introducing an initiator and a cross-linking agent,a method was prepared by freeze-thaw High strength wound dressing hydrogel.By controlling the content of PVA and PVP-I,freezing time,freezing and thawing cycles and other conditions,adjust the mechanical properties of hydrogel.The characterization methods of tensile test,infrared,XRD,SEM,ultraviolet and antibacterial experiments prove that the hydrogel has excellent mechanical strength,controlled release of iodine ions and antibacterial ability.(2)Using in-situ synthesis method,without cross-linking agent,chitosan(CS),polyacrylic acid(PAA)and gum arabic(AG)were mixed to prepare a high strength and high recovery rate Wound dressing hydrogel.Through tensile testing,immersion in different solutions,antibacterial testing and other methods,the relationship between the various interaction forces in the hydrogel has been proved in detail,confirming that the hydrogel has excellent mechanical strength and recovery rate,and has certain antibacterial ability.