Study On Green Synthesis Process Of 2-Phenylthioethanol

2-Phenylthioethanol is a special class of compounds in aryl sulfides.Because of its hydroxyl group,it has broad application prospects in medicine,organic synthesis and antioxidants.2-Phenylthioethanol is an important fine chemical raw material and intermediate,and it is desired to develop a green and efficient preparation method due to increasing demand in organic synthesis and medicinal chemistry.In this paper,the synthesis of 2-phenylthioethanol from thiophenol(PhSH)and ethylene carbonate(EC)is a new way of green synthesis.The experiments were carried out under homogeneous catalytic reaction and heterogeneous catalytic reaction,respectively.Homogeneous catalysis using the catalyst as DBN and DBU,The reaction process has a short time and mild conditions.Under the condition of EC/PhSH=1.1:1(molar ratio),the conversion of thiophenol and the yield of 2-phenylthioethanol are above 90%.The effects of catalyst dosage,time,temperature and functional groups substituted on the thiophenol ring on the product yield were investigated.The products were characterized by nuclear magnetic resonance spectroscopy.The structure of PhSH and DBN was determined by single crystal analysis to infer the reaction mechanism.Heterogeneous catalysis uses activated alumina as a catalyst.Since PhSH is a highly toxic chemical,continuous operation in a fixed bed reactor can reduce the damage of PhSH to the human body.The reaction process has good stability,strong selectivity,easy regeneration of the catalyst and easy separation from the reaction system.Under the condition of EC/PhSH=1.05:1(molar ratio),the conversion of thiophenol and the yield of 2-phenylthioethanol were above 99%.The effects of reaction temperature and different space velocity on the reaction yield were investigated.