Ni Catalyzed Coupling Reaction Of Aldehyde,1,3-diene And Nucleophile

Organic molecules with homoallyl alcohol structure are an important raw material and widely used in the synthesis of medicines,pesticides and natural products.The cheap metal Ni catalyzed coupling of aldehydes,1,3-dienes and nucleophiles is a very efficient way to construct the structure of the molecule.This kind of reaction has certain research value because it can introduce other very critical functional groups into this molecule.In the first part of this paper,Ni catalyzed the coupling of aldehydes,1,3-dienes and acylzirconium reagents to achieve the efficient synthesis of ?-hydroxyl-?,?-unsaturated ketones.In the second part of this paper,6-hydroxyl-2,8-DOBCOs and 6-amino-2,8-DOBCOs were synthesized from ?-hydroxyl-?,?-unsaturated ketones catalyzed by vanadium or copper.To sum up,2,8-bristlecone molecules containing biological activity can be synthesized efficiently with "one pot and two steps".