Construction Of Catalytic Nanoplatform For Tumor Treatment

Cancer is a critical illness which seriously threatens the health and quality of human life.Chemotherapy,radiotherapy and photodynamic therapy are conventional clinical cancer treatments,but they are limited,such as no targeting,large toxicity and PDT requires light irradiation.In recent years,emerging nanocatalytic therapeutic modality attracts much attention.It's targeting and no need light or other energy compared with other treatments.Chemodyamic therapy?CDT?refers to generating hydroxyl radical?·OH?in tumor sites via hydrogen peroxide?H₂O₂?catalyzed by transition metal ions in cancer cells under acidic environment.However,H₂O₂ content is not enough for effective CDT,although H₂O₂ content in cancer cells is higher than that of normal cells.Herein,we synthesized DOX@BSA-Cu NPs?nanoparticles?for effective CDT by providing enhanced content of H₂O₂ in cancer cells.The results proved Cu²⁺in NPs could be reduced to Cu⁺by glutathione?GSH?and effectively converted H₂O₂ to·OH.Moreover,the loaded low-dose doxorubicin?DOX?in the NPs could improve the content of H₂O₂ and resulted in more efficient generation of·OH in cancer cells.Thus compared with BSA-Cu,DOX@BSA-Cu NPs exhibited higher cytotoxicity to cancer cells.This research may provide new ideas for the further studies on more effective Cu?II?-based CDT nanoagents.Cancer starving therapy refers to inhibiting tumor growth by blocking the supply of nutrients.One of the most common methods is to inhibit providing energy for tumor metabolism by using glucose oxidase?GOx?to consume glucose in cancer cells.However,the enzyme is expensive and deactivated easily.Moreover,enzymatic reactions need“perfect”reaction condition.We synthesized a nanoplatform HMSN-Au for cancer treatment,ultrasmall Au nanoparticle exhibited glucose oxidase?GOx?-mimic activity and loaded on hollow mesoporous silica?HMSN?.The characterization of nanoparticles showed that HMSN-Au was synthesized and HMSN-Au could catalyze glucose effectively.Moreover,chemotherapeutic drugs or other agents can be further loaded due to the hollow structure of HMSN for multiple cancer treatments.