Application Of Metal Organic Framework Materials And Modification In Antibiotics Removal

Since the discovery of penicillin and streptomycin,antibiotics have developed rapidly.With the extensive use of antibiotics,they have caused potential harm to human health,environment and ecosystem.Antibiotics have been detected in many fields such as blood,meat and dairy products,water system and so on.Therefore,the removal of antibiotics has become an important and urgent problem.Metal-Organic Frameworks are widely used in adsorption,separation,catalysis and other fields because of their large specific surface area,controllable pore structure,unsaturated metal sites,various structures and functions.In this paper,Metal-Organic Frameworks were selected as adsorbent to remove antibiotics,and MOFs was modified to improve its adsorption capacity in combination with the properties of antibiotics.The main research contents are as follows:1.MIL-100?Fe?was synthesized and characterized by FT-IR,PXRD,TGA,SEM and N₂adsorption-desorption isotherm.At the same time,the adsorption properties of MIL-100?Fe?as adsorbent were studied.The results showed that MIL-100?Fe?had better adsorption effects on ceftriaxone sodium,cefoperazone sulbactam sodium,ceftazidime and meropenem,and the maximum adsorption capacity of ceftriaxone sodium was 426.00 mg/g.The kinetic model fitting showed that the adsorption process of MIL-100?Fe?on ceftriaxone sodium,ceftazidime and meropenem was in accordance with the pseudo-second-order kinetic model,so the adsorption rate of MIL-100?Fe?on antibiotics was controlled by the chemical adsorption mechanism.At the same time,MIL-100?Fe?could be reused after desorption and had a good cycle utilization ability.2.MIL-100?Fe?was modified by combining the properties of antibiotics.Zinc ions were added before the synthesis of MIL-100?Fe?to improve its ability to adsorb antibiotics.The results of FT-IR,PXRD,TGA,SEM and N₂ adsorption-desorption isotherm showed that MIL-100?Fe,Zn?was successfully synthesized and the stability of MIL-100?Fe,Zn?was good.The adsorption properties of MIL-100?Fe,Zn?for antibiotics were studied.The results showed that the adsorption efficiency of MIL-100?Fe,Zn?on ceftriaxone sodium,cefoperazone sulbactam sodium,ceftazidime and meropenem was improved by adding ions.At the same time,the adsorption efficiency of norfloxacin,ofloxacin and minocycline was improved significantly.The maximum adsorption capacity of MIL-100?Fe,Zn?for ceftriaxone sodium and norfloxacin reached 688.49 mg/g and 712.70 mg/g,respectively.The kinetics models of MIL-100?Fe,Zn?for ceftriaxone sodium,ceftazidime,meropenem,norfloxacin,ofloxacin and minocycline conformed to pseudo-second-order kinetics model.Regeneration experiments show that MIL-100?Fe,Zn?has good cyclic repeatability,and this adsorbent can be used to remove antibiotics from milk and blood,which is a potential good adsorbent.3.MIL-100?Fe?was modified by adding magnesium ion and copper ion to improve its adsorption capacity for antibiotics.The results showed that MIL-100?Fe?doped with Mg²⁺and Cu²⁺significantly increased the adsorption capacity for norfloxacin,ofloxacin and minocycline,and also increased the adsorption capacity for ceftriaxone sodium and ceftazidime.MIL-100?Fe,Mg?and MIL-100?Fe,Cu?have good recycling ability..The adsorbent can be used for the removal of antibiotics in milk and blood.It is a good adsorbent for antibiotics.By incorporating other metal ions into the original MOFs,the potential applications of MOFs in adsorption field can be increased.