Modification And Synthesis Process Design Of Cefidercol

Cefidercol is a new type of iron carrier cephalosporin,which has the function of penetrating the cell membrane of gram-negative bacteria.It enters the cell and binds to ferric iron.It binds to the receptor through the iron transport protein to inhibit the formation of bacterial cell wall and achieve antibacterial Active effect.Because of the unique antimicrobial mechanism and other patent protection period of cefadil,the major scientific researchers began to increase their research efforts on cefadil.In this paper,through the analysis of the inverse synthetic route of cefadiir,the monomer(a)and the derivative(a1)of the monomer(a),the monomer(b)and the monomer(c)are resolved through a series of The synthesis method of the module is modular synthesis,and each monomer is condensed and docked through some condensation methods to separate and purify.The drug modification is mainly to modify the structure of the C-7 side chain,through the modification of the monomer(d)and the monomer(d1),other parts of the fragment will not change,the modified C-7 side chain acid,Mainly the C-7 side chain acid of the fourth-generation cephalosporin.The fourth-generation cephalosporin is mainly used for the infection of drug-resistant bacteria.Due to the new antibacterial mechanism of cefodiere and the resistance of the fourth-generation cephalosporin,the second The combination of the two to detect the modified structure has the antibacterial activity of these two antibiotics.