Preparation Of Multifunctional Nanomaterials And Their Application In Tumors

Cancer seriously threatens human life and health.Due to many unsolved problems,the morbidity and mortality of cancer remain high.According to "CA: A Cancer Journal for Clinicians",in 2015,there were about 4.292 million cancer cases in China,accounting for 22% of the world;there were about 2.814 million cancer deaths in the world,accounting for 27% of the world.How to effectively prevent cancer and to detect and treat cancer patients early is particularly important.At present,there are three main types of traditional cancer treatments,radiotherapy,surgery,and chemotherapy.With the development of technology,many new cancer treatment methods have emerged,such as photothermal therapy,chemical kinetic therapy,and targeted therapy.Because monotherapy has serious limitations,including many side effects.Combining different treatment methods to co-operate to cope with diseases has become the mainstream cancer treatment method in today's world.In addition,bio-imaging-oriented treatment methods have also attracted extensive attention from a large number of researchers.In order to more effectively diagnose and treat cancer,and further meet the growing demand for efficient processing and multifunctional nanoplatform design,it is necessary to develop more effective treatment methods with fewer side effects.Based on the above problems,the research content of this paper is summarized as follows:The therapeutic diagnosis effect of cancer commonly depends on the cellular uptake efficiency of nanomaterials.However,the morphology of nanomaterials significantly affects cellular uptake capability.Herein,we designed a polydopamine-doped virus-like structured nanoparticles(GNR@HPMO@PVMSNs)composed of gold nanorod(GNR)cores,hollow periodic mesoporous organosilica(HPMO)shells and polydopamine-doped virus-like mesoporous silica nanoparticle(PVMSN)outer shells.Compared with conventional gold nanorod @ hollow periodic mesoporous organosilica core-shell nanoparticles(GNR@HPMO),GNR@HPMO@PVMSN with the virus-like structure was proved to enhance the efficiency of cellular uptake.The GNR@HPMO@PVMSN with the virtues of high photothermal conversion efficiency and good photoacoustic imaging(PAI)ability was expected to be a promising nanotheranostic agent for imaging guided cancer treatment.The experiments in vitro and in vivo proved that GNR@HPMO@PVMSN had good biocompatibility as well as photothermal conversion ability.In addition,DOX loading and p H-/NIRresponse DOX release abilities of GNR@HPMO@PVMSN were also verified in vitro.Therefore,the GNR@HPMO@PVMSN offers a promising strategy for PAI directed synergistic chemo-/photothermal therapy,which improves the therapeutic effect of the nanomaterial on tumors.This work explores the effects of rough surfaces on cellular uptake and provides a versatile theranostic platform for biomedical applications.